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Protein Page:
IL8RB (human)

Overview
IL8RB Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Receptor, cytokine; Membrane protein, integral; Receptor, GPCR; GPCR, family 1
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: cell surface; integral to plasma membrane; intracellular; mast cell granule; membrane; plasma membrane
Molecular Function: C-X-C chemokine receptor activity; interleukin-8 binding; interleukin-8 receptor activity; protein binding; signal transducer activity
Biological Process: cell surface receptor linked signal transduction; cellular defense response; chemotaxis; dendritic cell chemotaxis; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); inflammatory response; neutrophil activation; neutrophil chemotaxis; positive regulation of cell proliferation; receptor internalization; signal transduction
Reference #:  P25025 (UniProtKB)
Alt. Names/Synonyms: C-X-C chemokine receptor type 2; CD182; CDw128b; chemokine (C-X-C motif) receptor 2; chemokine (CXC) receptor 2; CMKAR2; CXC-R2; CXCR-2; CXCR2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8 receptor type 2; IL-8R B; IL8R2; IL8RA; IL8RB; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B
Gene Symbols: CXCR2
Molecular weight: 40,759 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
Select Structure to View Below

IL8RB

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
protein degradation: S347‑p, S351‑p, S352‑p, S353‑p
receptor desensitization, altered: S347‑p, S351‑p, S352‑p, S353‑p
receptor internalization, altered: S347‑p, S351‑p, S352‑p, S353‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 5 S347‑p LPKDSRPsFVGsssG
1 1 S351‑p SRPsFVGsssGHTST
1 1 S352‑p RPsFVGsssGHTSTT
1 0 S353‑p PsFVGsssGHTSTTL
  mouse

 
S346 LAKEGRPSFVSSSSA
S350 GRPSFVSSSSANTST
S351 RPSFVSSSSANTSTT
S352 PSFVSSSSANTSTTL
  rat

 
S346 LAKEGRPSFVGSSSA
S350 GRPSFVGSSSANTST
S351 RPSFVGSSSANTSTT
S352 PSFVGSSSANTSTTL
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