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Protein Page:
Rin1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Rin1 Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351. Expressed in all tissues examined with high levels in brain, placenta and pancreas. Belongs to the RIN (Ras interaction/interference) family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEFs; GEFs, Rab
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: cytoplasm; plasma membrane
Molecular Function: protein binding
Reference #:  Q13671 (UniProtKB)
Alt. Names/Synonyms: Ras and Rab interactor 1; ras inhibitor 1; Ras inhibitor JC99; ras inhibitor RIN1; Ras interaction/interference protein 1; RIN1
Gene Symbols: RIN1
Molecular weight: 84,099 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
Select Structure to View Below

Rin1

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S292‑p
cell motility, inhibited: S291‑p, S292‑p
intracellular localization: S351‑p
molecular association, regulation: S291‑p, S292‑p, S351‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 4 S3‑p _____MEsPGESGAG
0 3 S11‑p PGESGAGsPGAPsPS
0 3 S16‑p AGsPGAPsPSSFTTG
0 1 K29‑ub TGHLAREkPAQDPLy
0 1 A31 HLAREkPAQDPLyDV
0 4 Q32 LAREkPAQDPLyDVP
1 1046 Y36‑p kPAQDPLyDVPNAsG
0 4 S42‑p LyDVPNAsGGQAGGP
0 1 T65‑p LRERLLLtRPVWLQL
0 1 T90‑p LRTEPPGtFLVRKSN
1 0 Y121 PSFVSSHYILESPGG
1 0 Y148 LVQLICAYCHTRDIL
0 8 S210‑p LPQLKARsPQELDQG
0 2 T218‑p PQELDQGtGAALCFF
0 1 K237‑ub PGDLGPTkREKFKRs
0 1 S244‑p kREKFKRsFKVRVSt
0 1 T251‑p sFKVRVStETSsPLs
0 1 S255‑p RVStETSsPLsPPAV
0 3 S258‑p tETSsPLsPPAVPPP
1 22 S291‑p CQLLRREssVGyRVP
2 9 S292‑p QLLRREssVGyRVPA
0 4 Y295‑p RREssVGyRVPAGSG
0 2 S330‑p EEEGVPGsRGsPAts
0 13 S333‑p GVPGsRGsPAtsPHL
0 3 T336‑p GsRGsPAtsPHLGRR
0 17 S337‑p sRGsPAtsPHLGRRR
0 12 S349‑p RRRPLLRsMsAAFCS
3 20 S351‑p RPLLRsMsAAFCSLL
0 1 T377‑p ALMQDRHtAAGQLVQ
0 1 T388‑p QLVQDLLtQVRAGPE
0 1 S407‑p QGIRQALsRARAMLS
0 1 S424‑p LGPEKLLsPKRLEHV
0 8 A457 ARLRRRLAADGSLGR
0 1 K513‑ub YSPSAQVkRLLQACK
0 5 S601 QAHTLPLSPVQELRR
0 2 S609‑p PVQELRRsLsLWEQR
0 2 S611‑p QELRRsLsLWEQRRL
0 23 Y632‑p QHLLRVAyQDPSSGC
0 1 R664‑m1 QLCATKFrVTQPNTF
0 2 Y676‑p NTFGLFLyKEQGyHR
0 2 Y681‑p FLyKEQGyHRLPPGA
0 1 R692‑m1 PPGALAHrLPTtGyL
0 1 T696‑p LAHrLPTtGyLVyRR
0 6 Y698‑p HrLPTtGyLVyRRAE
0 6 Y701‑p PTtGyLVyRRAEWPE
0 3 S744‑p GDAGVKAsPRDIREQ
  Rin1 iso2  
S3 _____MESPGESGAG
S11 PGESGAGSPGAPSPS
S16 AGSPGAPSPSSFTTG
K29 TGHLAREKPAQDPLY
A31 HLAREKPAQDPLYDV
Q32 LAREKPAQDPLYDVP
Y36 KPAQDPLYDVPNASG
S42 LYDVPNASGGQAGGP
T65 LRERLLLTRPVWLQL
T90 LRTEPPGTFLVRKSN
Y121 PSFVSSHYILESPGG
Y148 LVQLICAYCHTRDIL
S210 LPQLKARSPQELDQG
T218 PQELDQGTGAALCFF
K237 PGDLGPTKREKFKRS
S244 KREKFKRSFKVRVST
T251 SFKVRVSTETSSPLS
S255 RVSTETSSPLSPPAV
S258 TETSSPLSPPAVPPP
S291 CQLLRRESSVGYRVP
S292 QLLRRESSVGYRVPA
Y295 RRESSVGYRVPAGSG
S330 EEEGVPGSRGSPATS
S333 GVPGSRGSPATSPHL
T336 GSRGSPATSPHLGRR
S337 SRGSPATSPHLGRRR
S349 RRRPLLRSMSAAFCS
S351 RPLLRSMSAAFCSLL
T377 ALMQDRHTAAGQLVQ
T388 QLVQDLLTQVRAGPE
S407 QGIRQALSRARAMLS
S424 LGPEKLLSPKRLELE
- gap
K451 YSPSAQVKRLLQACK
S539 QAHTLPLSPVQELRR
S547 PVQELRRSLSLWEQR
S549 QELRRSLSLWEQRRL
Y570 QHLLRVAYQDPSSGC
R602 QLCATKFRVTQPNTF
Y614 NTFGLFLYKEQGYHR
Y619 FLYKEQGYHRLPPGA
R630 PPGALAHRLPTTGYL
T634 LAHRLPTTGYLVYRR
Y636 HRLPTTGYLVYRRAE
Y639 PTTGYLVYRRAEWPE
S682 GDAGVKASPRDIREQ
  mouse

 
D3 _____MEDPGETGAH
P11 PGETGAHPLGATNLN
N16 AHPLGATNLNFVPGH
K28 PGHQQKEKPstDPLy
S30‑p HQQKEKPstDPLyDT
T31‑p QQKEKPstDPLyDTP
Y35‑p KPstDPLyDTPDTRG
R41 LyDTPDTRGVQAGGS
T64 LRERLLITRPVWLQL
T89 LRTEPPGTFLVRKSN
Y120‑p PSFVSSHyIEESTGG
Y147‑p LVQLICGyCRTRAIH
S198‑p IPRLKARsPQELDQG
T206 PQELDQGTGAALCFF
K225 PGDLGPTKREKFKRS
S232 KREKFKRSFKVRVST
T239 SFKVRVSTETSSPLs
S243 RVSTETSSPLsPPAV
S246‑p TETSSPLsPPAVPPP
S279 RQLLQRESsVGYRVP
S280‑p QLLQRESsVGYRVPG
Y283 QRESsVGYRVPGSAA
S316 SSSEEEGSSGSPTTS
S319 EEEGSSGSPTTSPRL
T322 GSSGSPTTSPRLSRP
S323 SSGSPTTSPRLSRPR
S338‑p HRRPLLRsMsSAFCS
S340‑p RPLLRsMsSAFCSLL
T366 MLMQNRYTAVGQLVQ
T377 QLVQDLLTQVRAGPE
S396 QGIRQALSRARAMLS
P413 LGPEKLLPPERLELV
S446‑p ARLRRRLsADGSLGR
K502 YSPSAQVKWLLQACK
S590‑p QARALPLsPAQELQR
S598 PAQELQRSLALWEQR
A600 QELQRSLALWEQRRL
Y621‑p QHLLRVAyQDPSTGC
R653 QLCATKFRVTQPDAF
Y665 DAFGLFLYKDQGYHR
Y670 FLYKDQGYHRLPPEA
R681 PPEALAHRLPATGYL
T685 LAHRLPATGYLIyRR
Y687 HRLPATGYLIyRRAE
Y690‑p PATGYLIyRRAERPE
- gap
  rat

 
D3 _____MEDPGETEAH
P11 PGETEAHPLGATSLN
S16 AHPLGATSLNFVPGY
K28 PGYQQEEKPSPDPLy
S30 YQQEEKPSPDPLyDT
P31 QQEEKPSPDPLyDTP
Y35‑p KPSPDPLyDTPDARG
R41 LyDTPDARGVQAGGS
T64 LRERLLITRPVWLQL
T89 LRTEPPGTFLVRKSN
Y120 PSFVSSHYLQESPGG
Y147 LVQLICAYCHTRDIL
S209 IPRLKARSPQELDQG
T217 PQELDQGTGAALCFF
K236 PGDLGPTKREKFKRS
S243 KREKFKRSFKVRVST
T250 SFKVRVSTETSSPLS
S254 RVSTETSSPLSPPAV
S257 TETSSPLSPPAVPPP
S290 RQLLQRESSVGYRVP
S291 QLLQRESSVGYRVPG
Y294 QRESSVGYRVPGSAS
S327 SSSEEEGSSGSPTTS
S330 EEEGSSGSPTTSPRL
T333 GSSGSPTTSPRLSRP
S334 SSGSPTTSPRLSRPR
S349 HRRPLLRSMsSAFCS
S351‑p RPLLRSMsSAFCSLL
T377 MLMQNRYTAVGQLVQ
T388 QLVQDLLTQVRVGPE
S407 QGIRQALSRARAMLS
P424 LGPEKLLPPERLELV
S457‑p ARLRRRLsTDGSLGR
K513 YSPSAQIKWLLQACK
S601 QAHALPLSPAQELQR
S609 PAQELQRSLALWEQR
A611 QELQRSLALWEQRRL
Y632‑p QHLLRVAyQDPSTGC
R664 QLCATKFRVTQPDAF
Y676 DAFGLFLYKDQGYHR
Y681 FLYKDQGYHRLPPEA
R692 PPEALVHRLPTTGYL
T696 LVHRLPTTGYLIyRR
Y698 HRLPTTGYLIyRRAE
Y701‑p PTTGYLIyRRAERPE
- gap
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