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Protein Page:
PKCZ (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKCZ an AGC kinase of the PKC family. An atypical PKC: its activity is not regulated by Ca2+, PS, DAG or phorbol esters. Constitutively active. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.13; Protein kinase, AGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Iota subfamily
Chromosomal Location of Human Ortholog: 1p36.33-p36.2
Cellular Component: cell junction; cytoplasm; cytosol; intercellular junction; membrane; plasma membrane; vesicle
Molecular Function: insulin receptor substrate binding; protein binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity
Biological Process: activation of NF-kappaB transcription factor; establishment of cell polarity; negative regulation of insulin receptor signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein complex assembly; peptidyl-serine phosphorylation; positive regulation of insulin receptor signaling pathway; positive regulation of interleukin-4 production; positive regulation of T-helper 2 cell differentiation; protein amino acid phosphorylation; signal transduction; transforming growth factor beta receptor signaling pathway
Reference #:  Q05513 (UniProtKB)
Alt. Names/Synonyms: KPCZ; nPKC-zeta; PKC-ZETA; PKC2; PRKCZ; Protein kinase C zeta type; protein kinase C, zeta
Gene Symbols: PRKCZ
Molecular weight: 67,660 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Mitochondrial Control of Apoptosis  |  NF-kB Signaling  |  Phospholipase Signaling  |  Protein Kinase C Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PKCZ

Protein Structure Not Found.
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Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cytoskeletal reorganization: T410‑p, T560‑p
enzymatic activity, induced: T410‑p, Y417‑p
molecular association, regulation: T410‑p
protein conformation: T410‑p, Y428‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T5 ___MPSRTGPKMEGS
0 1 T57 LHQQHPLTLKWVDSE
1 0 S113 PCPGEDKSIYRRGAR
0 1 S148 RAYCGQCSERIWGLA
0 1 S148‑p RAYCGQCsERIWGLA
0 1 R160 GLARQGYRCINCKLL
0 1 T179 CHGLVPLTCRKHMDS
2 0 S186 TCRKHMDSVMPsQEP
0 1 S190‑p HMDSVMPsQEPPVDD
1 0 S217 DGIAYISSSRKHDsI
1 0 S218 GIAYISSSRKHDsIK
0 4 S223‑p SSSRKHDsIKDDsED
0 1 S228‑p HDsIKDDsEDLKPVI
0 1 S262 IRVIGRGSYAKVLLV
0 1 Y263 RVIGRGSYAKVLLVR
0 2 R375 HERGIIYRDLKLDNV
0 1 T407‑p EGLGPGDtTstFCGT
0 1 S409‑p LGPGDtTstFCGTPN
41 11 T410‑p GPGDtTstFCGTPNy
1 0 Y417‑p tFCGTPNyIAPEILR
1 0 Y428‑p EILRGEEyGFSVDWW
0 1 K490 VKASHVLKGFLNKDP
0 1 K513 QTGFSDIKSHAFFRS
1 0 S520 KSHAFFRSIDWDLLE
11 5 T560‑p TSEPVQLtPDDEDAI
0 1 S591 LLLSTEESV______
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9378 : Phospho-PKCzeta/lambda (Thr410/403) Antibody
  PKCZ iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S3 _____MDSVMPSQEP
S7 _MDSVMPSQEPPVDD
S34 DGIAYISSSRKHDSI
S35 GIAYISSSRKHDSIK
S40 SSSRKHDSIKDDSED
S45 HDSIKDDSEDLKPVI
S79 IRVIGRGSYAKVLLV
Y80 RVIGRGSYAKVLLVR
R192 HERGIIYRDLKLDNV
T224 EGLGPGDTTSTFCGT
S226 LGPGDTTSTFCGTPN
T227 GPGDTTSTFCGTPNY
Y234 TFCGTPNYIAPEILR
Y245 EILRGEEYGFSVDWW
K307 VKASHVLKGFLNKDP
K330 QTGFSDIKSHAFFRS
S337 KSHAFFRSIDWDLLE
T377 TSEPVQLTPDDEDAI
S408 LLLSTEESV______
  PKCZ iso3  
- gap
- gap
S9 LTPRTDESIYRRGAR
S44 RAYCGQCSERIWGLA
S44 RAYCGQCSERIWGLA
R56 GLARQGYRCINCKLL
T75 CHGLVPLTCRKHMDS
S82 TCRKHMDSVMPSQEP
S86 HMDSVMPSQEPPVDD
S113 DGIAYISSSRKHDSI
S114 GIAYISSSRKHDSIK
S119 SSSRKHDSIKDDSED
S124 HDSIKDDSEDLKPVI
S158 IRVIGRGSYAKVLLV
Y159 RVIGRGSYAKVLLVR
R271 HERGIIYRDLKLDNV
T303 EGLGPGDTTSTFCGT
S305 LGPGDTTSTFCGTPN
T306 GPGDTTSTFCGTPNY
Y313 TFCGTPNYIAPEILR
Y324 EILRGEEYGFSVDWW
K386 VKASHVLKGFLNKDP
K409 QTGFSDIKSHAFFRS
S416 KSHAFFRSIDWDLLE
T456 TSEPVQLTPDDEDAI
S487 LLLSTEESV______
  mouse

 
T5‑p ___MPSRtDPKMDRS
T57 LHQQHPLTLKWVDSE
S113‑p PCPGEDKsIYRRGAR
S148 GAYCGQCSERIWGLS
S148 GAYCGQCSERIWGLS
R160‑m1 GLSRQGYrCINCKLL
T179 CHVLVPLTCRRHMDs
S186‑p TCRRHMDsVMPSQEP
S190 HMDsVMPSQEPPVDD
S217‑p DGIAYISssRKHDNI
S218‑p GIAYISssRKHDNIK
N223 SssRKHDNIKDDSED
S228 HDNIKDDSEDLKPVI
S262 IRVIGRGSYAKVLLV
Y263 RVIGRGSYAKVLLVR
R375‑m1 HERGIIYrDLKLDNV
T407 EGLGPGDTTstFCGT
S409‑p LGPGDTTstFCGTPN
T410‑p GPGDTTstFCGTPNY
Y417 tFCGTPNYIAPEILR
Y428 EILRGEEYGFSVDWW
K490 VKASHVLKGFLNKDP
K513‑ac QTGFSDIkSHAFFRs
S520‑p kSHAFFRsIDWDLLE
T560‑p TSEPVQLtPDDEDVI
S591 LLLSAEESV______
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9378 : Phospho-PKCzeta/lambda (Thr410/403) Antibody
  rat

 
T5 ___MPSRTDPKMDRS
T57‑gl LHQQHPLtLKWVDSE
S113 PCPGEDKSIYRRGAR
S148‑gl RAYCGQCsERIWGLA
S148 RAYCGQCSERIWGLA
R160 GLARQGYRCINCKLL
T179‑gl CHVLVPLtCRRHMDs
S186‑p tCRRHMDsVMPSQEP
S190 HMDsVMPSQEPPVDD
S217 DGIAYISSSRKHDNI
S218 GIAYISSSRKHDNIK
N223 SSSRKHDNIKDDSED
S228 HDNIKDDSEDLKPVI
S262‑p IRVIGRGsyAKVLLV
Y263‑p RVIGRGsyAKVLLVR
R375 HERGIIYRDLKLDNV
T407 EGLGPGDTTStFCGT
S409 LGPGDTTStFCGTPN
T410‑p GPGDTTStFCGTPNY
Y417 tFCGTPNYIAPEILR
Y428 EILRGEEYGFSVDWW
K490‑ac VKASHVLkGFLNKDP
K513 QTGFSDIKSHAFFRS
S520 KSHAFFRSIDWDLLE
T560‑p TSEPVQLtPDDEDVI
S591‑p LLLSAEEsV______
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9378 : Phospho-PKCzeta/lambda (Thr410/403) Antibody
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