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Protein Page:
ATP7B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATP7B Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. Monomer. Interacts with COMMD1/MURR1. Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Vesicle; Transporter; EC 3.6.3.54; Membrane protein, integral; Membrane protein, multi-pass; Hydrolase; Transporter, ion channel
Chromosomal Location of Human Ortholog: 13q14.3
Cellular Component: basolateral plasma membrane; cytoplasmic membrane-bound vesicle; Golgi membrane; integral to plasma membrane; late endosome; membrane; perinuclear region of cytoplasm; trans-Golgi network; trans-Golgi network membrane
Molecular Function: ATP binding; copper ion binding; copper-exporting ATPase activity; copper-transporting ATPase activity; protein binding
Biological Process: cellular copper ion homeostasis; copper ion import; copper ion transport; response to copper ion; sequestering of calcium ion
Disease: Wilson Disease
Reference #:  P35670 (UniProtKB)
Alt. Names/Synonyms: ATP7B; ATPase, Cu(2+)- transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide; Copper pump 2; Copper-transporting ATPase 2; PWD; WC1; WD; Wilson disease-associated protein; WND; WND/140 kDa
Gene Symbols: ATP7B
Molecular weight: 157,263 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Select Structure to View Below

ATP7B

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
intracellular localization: S340‑p, S341‑p
protein conformation: S340‑p, S341‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 T9‑p PEQERQItAREGASR
0 1 S15 ItAREGASRKILSKL
0 1 S23‑p RKILSKLsLPTRAWE
0 1 S81 KSIEDRISNLKGIIS
0 1 N82 SIEDRISNLKGIISM
0 4 S132 IAEGKAASWPSRSLP
0 2 L138 ASWPSRSLPAQEAVV
0 1 V214 EAAIKSKVAPLSLGP
0 1 S229‑p IDIERLQsTNPKRPL
0 1 S326 PPGNFKVSLPDGAEG
1 0 S340‑p GSGTDHRssSSHSPG
1 0 S341‑p SGTDHRssSSHSPGS
0 1 - gap
0 1 S444 GNHSAGNSMVQTTDG
0 1 T452 MVQTTDGTPTSVQEV
0 1 A476 NHAPDILAKsPQsTR
2 4 S478‑p APDILAKsPQsTRAV
2 4 S481‑p ILAKsPQsTRAVAPQ
0 1 K489‑ub TRAVAPQkCFLQIKG
0 1 S518‑p QKEAGVLsVLVALMA
0 1 K607‑ub ATSKALVkFDPEIIG
0 1 K785 RWLEHLAKSKTSEAL
0 1 K794 KTSEALAKLMSLQAT
0 1 K1028‑ac IKTVMFDkTGTITHG
0 1 K1028‑ub IKTVMFDkTGTITHG
0 1 T1050‑p LLLGDVAtLPLRKVL
0 1 S1066 VVGTAEASSEHPLGV
0 1 T1076‑p HPLGVAVtKyCKEEL
0 1 Y1078‑p LGVAVtKyCKEELGT
2 1 S1121‑p AHSERPLsAPASHLN
0 1 T1143 EKDAVPQTFSVLIGN
0 1 S1145 DAVPQTFSVLIGNRE
0 1 S1163 RNGLTISSDVSDAMT
0 1 T1208‑p EAALAVHtLQsMGVD
0 2 S1211‑p LAVHtLQsMGVDVVL
0 1 T1220‑p GVDVVLItGDNRKTA
0 7 K1258‑ac KVQELQNkGkKVAMV
0 7 K1260‑ac QELQNkGkKVAMVGD
0 1 T1396 HGHMKPLTAsQVsVH
0 4 S1398‑p HMKPLTAsQVsVHIG
0 6 S1401‑p PLTAsQVsVHIGMDD
0 1 S1413‑p MDDRWRDsPRATPWD
0 1 S1423‑p ATPWDQVsYVsQVSL
0 1 S1426‑p WDQVsYVsQVSLSSL
2 6 S1453‑p DDDGDKWsLLLNGRD
0 1 N1457 DKWsLLLNGRDEEQY
  ATP7B iso2  
T9 PEQERQITAREGASR
S15 ITAREGASRKILSKL
S23 RKILSKLSLPTRAWE
S81 KSIEDRISNLKGIIS
N82 SIEDRISNLKGIISM
S132 IAEGKAASWPSRSLP
L138 ASWPSRSLPAQEAVV
V214 EAAIKSKVAPLSLGP
S229 IDIERLQSTNPKRPL
S326 PPGNFKVSLPDGAEG
S340 GSGTDHRSSSSHSPG
S341 SGTDHRSSSSHSPGS
- gap
S444 GNHSAGNSMVQTTDG
T452 MVQTTDGTPTSVQEV
A476 NHAPDILAKSPQSTR
S478 APDILAKSPQSTRAV
S481 ILAKSPQSTRAVAPQ
K489 TRAVAPQKCFLQIKG
S518 QKEAGVLSVLVALMA
K607 ATSKALVKFDPEIIG
- gap
K632 KTSEALAKLMSLQAT
K821 IKTVMFDKTGTITHG
K821 IKTVMFDKTGTITHG
T843 LLLGDVATLPLRKVL
S859 VVGTAEASSEHPLGV
T869 HPLGVAVTKYCKEEL
Y871 LGVAVTKYCKEELGT
S914 AHSERPLSAPASHLN
T936 EKDAVPQTFSVLIGN
S938 DAVPQTFSVLIGNRE
S956 RNGLTISSDVSDAMT
T1001 EAALAVHTLQSMGVD
S1004 LAVHTLQSMGVDVVL
T1013 GVDVVLITGDNRKTA
K1051 KVQELQNKGKKVAMV
K1053 QELQNKGKKVAMVGD
T1189 HGHMKPLTASQVSVH
S1191 HMKPLTASQVSVHIG
S1194 PLTASQVSVHIGMDD
S1206 MDDRWRDSPRATPWD
S1216 ATPWDQVSYVSQVSL
S1219 WDQVSYVSQVSLSSL
S1246 DDDGDKWSLLLNGRD
N1250 DKWSLLLNGRDEEQY
  mouse

 
T21‑p PEQERQVtAKEAsRK
S26‑p QVtAKEAsRKILSKL
A34 RKILSKLALPGRPWE
S91‑p KSIEDRIssLKGIVN
S92‑p SIEDRIssLKGIVNI
S142‑p AAEGKAAsWPSRSsP
S148‑p AsWPSRSsPAQEAVV
T224 EAAIKNRTAPLRLGP
S239 IDVNKLESTNLKKET
S336 PPGHFKVSLPDGVEE
- gap
- gap
K442‑ub INPVRNFkSGNsVPQ
S446‑p RNFkSGNsVPQTMGD
I454 VPQTMGDIAGSVQKM
S478 HQGPGHSSETPSSPG
T480 GPGHSSETPSSPGAT
S483 HSSETPSSPGATASQ
K491 PGATASQKCFVQIKG
S520 QRHAGILSVLVALMS
K609 ATSKAHVKFDPEIVG
K787‑ac RWLEHVAkSKTSEAL
K796‑ac KTSEALAkLMSLQAT
K1030 IKTVMFDKTGTITHG
K1030 IKTVMFDKTGTITHG
T1052 LLLADVATLPLRKVL
S1068‑p VVGTAEAsSEHPLGV
T1078 HPLGVAVTKYCKEEL
Y1080 LGVAVTKYCKEELGT
- gap
T1140‑p GEGAGPQtFsVLIGN
S1142‑p GAGPQtFsVLIGNRE
S1160‑p RNGLTISsDISDAMT
T1205 EAALAIYTLKsMGVD
S1208‑p LAIYTLKsMGVDVAL
T1217 GVDVALITGDNRKTA
E1255 KVQELQNEGKKVAMV
K1257 QELQNEGKKVAMVGD
S1393‑p HGRMKPLsAsQVsVH
S1395‑p RMKPLsAsQVsVHIG
S1398‑p PLsAsQVsVHIGMDD
S1410 MDDRRRDSPRATAWD
S1420 ATAWDQVSYVSQVSL
S1423 WDQVSYVSQVSLSSL
S1450‑p EDGGDKWsLLLSDRD
S1454 DKWsLLLSDRDEEQC
  rat

 
T9 PEQERKVTAKEASRK
S14 KVTAKEASRKILSKL
A22 RKILSKLALPTRPWG
S80 KSIEDRISSLKGIVS
S81 SIEDRISSLKGIVSI
S131‑p AAEGKAAsWPSRSSP
S137 AsWPSRSSPAQEAVV
T213‑p EAAIKNRtAPLRLGP
S228 IDINKLESTNLKRAA
S325‑p PPGYFKVsLPDGLEK
S336 GLEKESGSSSVPSLG
S337 LEKESGSSSVPSLGS
- gap
S437 NRVSSGNSVPQAVGD
S445‑p VPQAVGDsPGSVQNM
S469‑p HQGPGYLsDsPPsPG
S471‑p GPGYLsDsPPsPGGT
S474‑p YLsDsPPsPGGTASQ
K482 PGGTASQKCFVQIKG
S511 QRHAGILSVLVALMS
K600 ATSKAHVKFDPEIIG
K778 RWLEHVAKSKTSEAL
K787 KTSEALAKLMSLQAT
K1021 IKTVMFDKTGTITHG
K1021 IKTVMFDKTGTITHG
T1043 LLLVDVATLSLRKVL
S1059 VVGTAEASSEHPLGV
T1069 HPLGVAVTKYCKEEL
Y1071 LGVAVTKYCKEELGT
- gap
T1131 GEGTGPQTFSVLIGN
S1133 GTGPQTFSVLIGNRE
S1151 RNGLTISSDISDAMT
T1196 EAALASITLKSMGVD
S1199 LASITLKSMGVDVAL
T1208 GVDVALITGDNRKTA
K1246 KVQELQNKGKKVAMV
K1248 QELQNKGKKVAMVGD
S1382 HGRMKPLSAsQVsVH
S1384‑p RMKPLSAsQVsVHVG
S1387‑p PLSAsQVsVHVGMDD
S1399 MDDRRRDSPRATPWD
S1409 ATPWDQVSYVSQVSL
S1412 WDQVSYVSQVSLSSL
S1439 EDGGDKWSLLLsDRD
S1443‑p DKWSLLLsDRDEEQC
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