a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; EC 184.108.40.206; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Tec family
Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; extrinsic to internal side of plasma membrane; intracellular membrane-bound organelle; lipid raft; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: identical protein binding; non-membrane spanning protein tyrosine kinase activity; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein-tyrosine kinase activity
Biological Process: cell maturation; histamine secretion by mast cell; I-kappaB kinase/NF-kappaB cascade; innate immune response; negative regulation of cytokine production; peptidyl-tyrosine phosphorylation; positive regulation of type I hypersensitivity; positive regulation of type III hypersensitivity; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; response to organic substance; transmembrane receptor protein tyrosine kinase signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.