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Protein Page:
PTS (human)

PTS Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin. Defects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A); also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet. Belongs to the PTPS family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - folate biosynthesis; EC; Lyase; Mitochondrial
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: cytoplasm; cytosol; mitochondrion
Molecular Function: 6-pyruvoyltetrahydropterin synthase activity; identical protein binding
Biological Process: amino acid metabolic process; central nervous system development; regulation of nitric-oxide synthase activity
Disease: Hyperphenylalaninemia, Bh4-deficient, A
Reference #:  Q03393 (UniProtKB)
Alt. Names/Synonyms: 6-pyruvoyl tetrahydrobiopterin synthase; 6-pyruvoyltetrahydropterin synthase; FLJ97081; PTP synthase; PTPS; PTS
Gene Symbols: PTS
Molecular weight: 16,386 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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