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Protein Page:
MIF (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MIF a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. Also acts as a phenylpyruvate tautomerase. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tyrosine; Cell development/differentiation; EC 5.3.3.12; Amino Acid Metabolism - phenylalanine; EC 5.3.2.1; Apoptosis; Isomerase; Cytokine
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component: cell surface; cytoplasm; extracellular region; extracellular space; myelin sheath; nucleoplasm; vesicle
Molecular Function: chemoattractant activity; cytokine activity; dopachrome isomerase activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; phenylpyruvate tautomerase activity; protein binding; receptor binding
Biological Process: carboxylic acid metabolic process; cell aging; cell proliferation; cell surface receptor linked signal transduction; DNA damage response, signal transduction by p53 class mediator; inflammatory response; innate immune response; leukocyte migration; negative regulation of apoptosis; negative regulation of cellular protein metabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of mature B cell apoptosis; negative regulation of myeloid cell apoptosis; positive chemotaxis; positive regulation of B cell proliferation; positive regulation of cytokine secretion; positive regulation of fibroblast proliferation; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of MAP kinase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphorylation; prostaglandin biosynthetic process; regulation of macrophage activation
Disease: Rheumatoid Arthritis, Systemic Juvenile
Reference #:  P14174 (UniProtKB)
Alt. Names/Synonyms: GIF; GLIF; Glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; Macrophage migration inhibitory factor; macrophage migration inhibitory factor (glycosylation-inhibiting factor); MIF; MMIF; Phenylpyruvate tautomerase
Gene Symbols: MIF
Molecular weight: 12,476 Da
Basal Isoelectric point: 7.73  Predict pI for various phosphorylation states
Select Structure to View Below

MIF

Protein Structure Not Found.
Download PyMol Script
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T8‑p MPMFIVNtNVPrAsV
0 1 R12‑m1 IVNtNVPrAsVPDGF
0 1 S14‑p NtNVPrAsVPDGFLs
0 1 S21‑p sVPDGFLsELTQQLA
0 13 Y37‑p ATGKPPQyIAVHVVP
0 1 S75‑p IGGAQNRsYSkLLCG
0 14 K78‑ac AQNRsYSkLLCGLLA
0 79 K78‑ub AQNRsYSkLLCGLLA
1 3 S91‑p LAERLRIsPDRVYIN
0 4 Y99‑p PDRVYINyyDMNAAN
0 1 Y100‑p DRVYINyyDMNAANV
1 0 S112‑gl ANVGWNNstFA____
1 0 T113‑gl NVGWNNstFA_____
  mouse

 
T8 MPMFIVNTNVPRASV
R12 IVNTNVPRASVPEGF
S14 NTNVPRASVPEGFLS
S21 SVPEGFLSELTQQLA
Y37‑p ATGKPAQyIAVHVVP
N75 IGGAQNRNYSkLLCG
K78‑ac AQNRNYSkLLCGLLS
K78‑ub AQNRNYSkLLCGLLS
S91‑p LSDRLHIsPDRVYIN
Y99 PDRVYINYYDMNAAN
Y100 DRVYINYYDMNAANV
S112 ANVGWNGSTFA____
T113 NVGWNGSTFA_____
  rat

 
T8 MPMFIVNTNVPRASV
R12 IVNTNVPRASVPEGF
S14 NTNVPRASVPEGFLS
S21 SVPEGFLSELTQQLA
Y37 ATGKPAQYIAVHVVP
N75 IGGAQNRNYSkLLCG
K78‑ac AQNRNYSkLLCGLLS
K78‑ub AQNRNYSkLLCGLLS
S91‑p LSDRLHIsPDRVYIN
Y99 PDRVYINYYDMNAAN
Y100 DRVYINYYDMNAANV
S112 ANVGWNGSTFA____
T113 NVGWNGSTFA_____
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