a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc.
Cellular Component: cell surface; cilium; cytoplasm; integral to membrane; integral to plasma membrane; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex
Molecular Function: calcium ion binding; enzyme binding; NF-kappaB binding; protein binding
Biological Process: bone remodeling; cell cycle arrest; cell differentiation; cell fate determination; cell growth; defense response to bacterium; determination of left/right symmetry; embryonic limb morphogenesis; heart looping; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; liver development; marginal zone B cell differentiation; morphogenesis of an epithelial sheet; multicellular organism growth; multicellular organismal development; myeloid dendritic cell differentiation; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; organ morphogenesis; placenta development; positive regulation of apoptosis; positive regulation of BMP signaling pathway; positive regulation of cell proliferation; positive regulation of osteoclast differentiation; positive regulation of Ras protein signal transduction; regulation of developmental process; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent; wound healing
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.