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eIF2B-beta
eukaryotic translation initiation factor 2B, subunit 5. A translational regulatory protein that functions in the early steps of protein synthesis by catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutation in EIF2B5 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; GEF; GEF, misc.; RNA-binding; Translation |
| Chromosomal Location of Human Ortholog: 14q24.3 |
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Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex
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Molecular Function: ATP binding; GTP binding; guanyl-nucleotide exchange factor activity; protein binding; translation initiation factor activity
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Biological Process: cellular response to stimulus; central nervous system development; myelination; oligodendrocyte development; ovarian follicle development; regulation of translational initiation; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translational initiation
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Disease: Leukoencephalopathy With Vanishing White Matter
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Reference #:
P49770
(UniProtKB)
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Alt. Names/Synonyms: EI2BB; eIF-2B GDP-GTP exchange factor subunit beta; EIF-2Bbeta; EIF2B; EIF2B2; EIF2BB; eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa; S20I15; S20III15; Translation initiation factor eIF-2B subunit beta
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Gene Symbols: EIF2B2
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Molecular weight:
38,990 Da
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Basal Isoelectric point:
5.77
Predict pI for various phosphorylation states
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CST Pathways:
Translation: eIF2
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Translational Control
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