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Protein Page:
eIF2B-beta (human)

eIF2B-beta eukaryotic translation initiation factor 2B, subunit 5. A translational regulatory protein that functions in the early steps of protein synthesis by catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutation in EIF2B5 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; GEFs; GEFs, misc.; RNA-binding; Translation
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex
Molecular Function: ATP binding; GTP binding; guanyl-nucleotide exchange factor activity; protein binding; S-methyl-5-thioribose-1-phosphate isomerase activity; translation initiation factor activity
Biological Process: cellular response to stimulus; central nervous system development; methionine salvage; myelination; oligodendrocyte development; ovarian follicle development; regulation of translational initiation; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translational initiation
Disease: Leukoencephalopathy With Vanishing White Matter
Reference #:  P49770 (UniProtKB)
Alt. Names/Synonyms: EI2BB; eIF-2B GDP-GTP exchange factor subunit beta; EIF-2Bbeta; EIF2B; EIF2B2; EIF2BB; eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa; S20I15; S20III15; Translation initiation factor eIF-2B subunit beta
Gene Symbols: EIF2B2
Molecular weight: 38,990 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
Select Structure to View Below


Protein Structure Not Found.

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