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Protein Page:
TRPV1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TRPV1 a receptor for capsaicin and a non-selective cation channel that is structurally related to members of the TRP family of ion channels. Activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Channel, cation; Receptor, misc.; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component: integral to membrane; integral to plasma membrane; intrinsic to plasma membrane; plasma membrane; postsynaptic membrane
Molecular Function: ATP binding; calcium channel activity; calcium-release channel activity; excitatory extracellular ligand-gated ion channel activity; phosphoprotein binding; transmembrane receptor activity
Biological Process: cell surface receptor linked signal transduction; chemosensory behavior; thermoception; transport
Reference #:  Q8NER1 (UniProtKB)
Alt. Names/Synonyms: Capsaicin receptor; DKFZp434K0220; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel, subfamily V, member 1; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; TRPV1; Vanilloid receptor 1; vanilloid receptor subtype 1; VR1
Gene Symbols: TRPV1
Molecular weight: 94,956 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
Select Structure to View Below

TRPV1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
activity, induced: T705‑p
intracellular localization: Y200‑p, S502‑p
receptor desensitization, altered: Y200‑p, S502‑p, S801‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S5‑p ___MKKWsstDLGAA
1 1 S6‑p __MKKWsstDLGAAA
0 1 T7‑p _MKKWsstDLGAAAD
6 1 S117‑p LRLYDRRsIFEAVAQ
0 2 S132‑p NNCQDLEsLLLFLQK
0 1 S140‑p LLLFLQKsKKHLTDN
5 0 T145 QKsKKHLTDNEFKDP
0 1 K161‑ac TGKTCLLkAMLNLHD
0 1 T196‑p ELVNASYtDSYyKGQ
2 0 Y200‑p ASYtDSYyKGQTALH
0 1 K266 TNQLGIVKFLLQNSW
0 1 T330 TLKLEELTNKKGMtP
0 1 T336‑p LTNKKGMtPLALAAG
4 0 T371 RHLSRKFTEWAYGPV
3 0 T407 IAYSSSETPNRHDML
15 0 S502‑p YFLQRRPsMKTLFVD
5 0 T705‑p WKLQRAItILDTEKS
0 2 T773‑p NCEGVKRtLsFSLRs
3 1 S775‑p EGVKRtLsFSLRsSR
0 1 S780‑p tLsFSLRsSRVSGRH
17 0 S801‑p VPLLREAsARDRQsA
0 1 S807‑p AsARDRQsAQPEEVy
0 1 Y814‑p sAQPEEVyLRQFSGS
2 0 S821 yLRQFSGSLKPEDAE
  mouse

 
A5 ___MEKWASLDSDES
S6 __MEKWASLDSDESE
S9 EKWASLDSDESEPPA
S117 PRLYDRRSIFDAVAQ
S132 SNCQELESLLSFLQK
S140 LLSFLQKSKKRLtDS
T145‑p QKSKKRLtDSEFKDP
K161 TGKTCLLKAMLNLHN
T196 QFVNASYTDSYYKGQ
Y200 ASYTDSYYKGQTALH
K266‑ac TNQLAIVkFLLQNSW
T330‑p TLKLEELtNKKGLTP
T336 LtNKKGLTPLALAAS
T371‑p RHLSRKFtEWAYGPV
T407‑p IAYSSSEtPNRHDML
S503 YFLQRRPSLKSLFVD
T705 WKLQRAITILDTEKS
T773 NCEGVKRTLSFSLRS
S775 EGVKRTLSFSLRSGR
S780 TLSFSLRSGRVSGRN
S801‑p VPLLRDAsTRDRHST
S807 AsTRDRHSTQPEEVQ
Q814 STQPEEVQLKHYTGS
S821 QLKHYTGSLKPEDAE
  rat

 
A5 ___MEQRAsLDSEES
S6‑p __MEQRAsLDSEESE
S9 EQRAsLDSEESESPP
S116‑p PRLYDRRsIFDAVAQ
S131 SNCQELESLLPFLQR
S139 LLPFLQRSKKRLtDS
T144‑p QRSKKRLtDSEFKDP
K160 TGKTCLLKAMLNLHN
T195 QFVNASYTDSYyKGQ
Y199‑p ASYTDSYyKGQTALH
K265 TNQLAIVKFLLQNSW
T329 TLKLEEITNRKGLTP
T335 ITNRKGLTPLALAAS
T370‑p RHLSRKFtEWAYGPV
T406‑p IAYSSSEtPNRHDML
S502‑p YFLQRRPsLKSLFVD
T704‑p WKLQRAItILDTEKS
T772 NCEGVKRTLsFSLRS
S774‑p EGVKRTLsFSLRSGR
S779 TLsFSLRSGRVSGRN
S800‑p VPLLRDAsTRDRHAT
A806 AsTRDRHATQQEEVQ
Q813 ATQQEEVQLKHYTGs
S820‑p QLKHYTGsLKPEDAE
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