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Protein Page:
CFTR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CFTR a member of the MRP subfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. Functions as a chloride channel and controls the regulation of other transport pathways. Mutations have been observed in patients with the autosomal recessive disorders cystic fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD). Alternative splice Note: This description may include information from UniProtKB.
Protein type: Transporter, ABC family; EC 3.6.3.49; Membrane protein, multi-pass; Membrane protein, integral; Hydrolase; Channel, chloride; Transporter
Chromosomal Location of Human Ortholog: 7q31.2
Cellular Component: apical plasma membrane; basolateral plasma membrane; cell surface; cytoplasm; cytosol; early endosome; early endosome membrane; lysosomal membrane; plasma membrane; protein complex; recycling endosome
Molecular Function: anion transmembrane-transporting ATPase activity; ATP binding; ATP-binding and phosphorylation-dependent chloride channel activity; bicarbonate transmembrane transporter activity; channel-conductance-controlling ATPase activity; chloride channel activity; chloride channel inhibitor activity; chloride channel regulator activity; chloride transmembrane transporter activity; enzyme binding; PDZ domain binding; protein binding
Biological Process: bicarbonate transport; cholesterol biosynthetic process; cholesterol transport; intracellular pH elevation; membrane hyperpolarization; positive regulation of exocytosis; respiratory gaseous exchange; sperm capacitation; transmembrane transport; transport; vesicle docking during exocytosis
Disease: Bronchiectasis With Or Without Elevated Sweat Chloride 1; Cystic Fibrosis; Pancreatitis, Hereditary; Vas Deferens, Congenital Bilateral Aplasia Of
Reference #:  P13569 (UniProtKB)
Alt. Names/Synonyms: ABC35; ABCC7; ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; cAMP-dependent chloride channel; CF; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; Cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); dJ760C5.1; MRP7; TNR-CFTR
Gene Symbols: CFTR
Molecular weight: 168,142 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CFTR

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
endocytosis, induced: S737‑p
activity, induced: S422‑p, S511‑p, T582‑p, T604‑p, S641‑p, S660‑p, T682‑p, S686‑p, S707‑p, S737‑p, S768‑p, S790‑p, S795‑p, S813‑p
activity, inhibited: S641‑p, T682‑p, S737‑p, S768‑p, T1471‑p
enzymatic activity, inhibited: S660‑p, S700‑p, S712‑p, S737‑p, S768‑p, S795‑p, S813‑p
intracellular localization: S422‑p, Y512‑p, T1471‑p
molecular association, regulation: S660‑p, S700‑p, S712‑p, S737‑p, S768‑p, S795‑p, S813‑p
protein conformation: S660‑p, S737‑p, S795‑p, S813‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S45‑p YQIPSVDsADNLsEK
0 1 S50‑p VDsADNLsEKLEREW
0 1 T94‑p FLYLGEVtKAVQPLL
0 1 S256‑p DQRAGKIsERLVITS
0 1 T291‑p MIENLRQtELKLTRK
0 2 K420‑ub KQNNNNRkTsNGDDS
4 0 S422‑p NNNNRkTsNGDDSLF
1 0 K447‑sm VLKDINFkIERGQLL
2 0 S511‑p ENIIFGVsyDEyRYR
2 0 Y512‑p NIIFGVsyDEyRYRS
0 1 Y515‑p FGVsyDEyRYRSVIK
0 1 Y517 VsyDEyRYRSVIKAC
0 3 S549‑p GEGGITLsGGQRARI
2 0 T582‑p FGYLDVLtEKEIFES
2 1 T604‑p NKTRILVtsKMEHLK
0 1 S605‑p KTRILVtsKMEHLKK
2 0 S641‑p QNLQPDFsSKLMGCD
1 0 N659 QFSAERRNsILTETL
8 2 S660‑p FSAERRNsILTETLH
4 0 S670‑p TETLHRFsLEGDAPV
2 0 T682‑p APVSWTEtKKQsFKQ
4 0 S686‑p WTEtKKQsFKQTGEF
8 2 S700‑p FGEKRKNsILNPINs
2 0 S707‑p sILNPINsIRKFsIV
5 1 S712‑p INsIRKFsIVQKTPL
1 0 S728 MNGIEEDSDEPLERR
15 2 S737‑p EPLERRLsLVPDSEQ
1 0 S742 RLsLVPDSEQGEAIL
3 0 S753‑p EAILPRIsVISTGPT
13 1 S768‑p LQARRRQsVLNLMtH
0 2 T774‑p QsVLNLMtHsVNQGQ
0 2 S776‑p VLNLMtHsVNQGQNI
2 0 S790‑p IHRKTTAsTRKVsLA
8 2 S795‑p TAsTRKVsLAPQANL
1 1 S809‑p LTELDIYsRRLsQET
9 1 S813‑p DIYsRRLsQETGLEI
1 1 T816 sRRLsQETGLEISEE
0 1 Y1014‑p VVAVLQPyIFVAtVP
0 1 T1019‑p QPyIFVAtVPVIVAF
0 1 T1176‑p MPTEGKPtKSTKPYK
1 0 - gap
0 1 S1362‑p CLARSVLsKAKILLL
0 1 Y1424‑p EENKVRQyDSIQKLL
0 1 S1455 KLFPHRNSSKCKSKP
0 1 S1456 LFPHRNSSKCKSKPQ
2 0 T1471‑p IAALKEEtEEEVQDT
  CFTR iso2  
S45 YQIPSVDSADNLSEK
S50 VDSADNLSEKLEREW
T94 FLYLGEVTKAVQPLL
S256 DQRAGKISERLVITS
T291 MIENLRQTELKLTRK
- gap
- gap
- gap
S450 ENIIFGVSYDEYRYR
Y451 NIIFGVSYDEYRYRS
Y454 FGVSYDEYRYRSVIK
Y456 VSYDEYRYRSVIKAC
S488 GEGGITLSGGQRARI
T521 FGYLDVLTEKEIFES
T543 NKTRILVTSKMEHLK
S544 KTRILVTSKMEHLKK
S580 QNLQPDFSSKLMGCD
N598 QFSAERRNSILTETL
S599 FSAERRNSILTETLH
S609 TETLHRFSLEGDAPV
T621 APVSWTETKKQSFKQ
S625 WTETKKQSFKQTGEF
S639 FGEKRKNSILNPINS
S646 SILNPINSIRKFSIV
S651 INSIRKFSIVQKTPL
S667 MNGIEEDSDEPLERR
S676 EPLERRLSLVPDSEQ
S681 RLSLVPDSEQGEAIL
S692 EAILPRISVISTGPT
S707 LQARRRQSVLNLMTH
T713 QSVLNLMTHSVNQGQ
S715 VLNLMTHSVNQGQNI
S729 IHRKTTASTRKVSLA
S734 TASTRKVSLAPQANL
S748 LTELDIYSRRLSQET
S752 DIYSRRLSQETGLEI
T755 SRRLSQETGLEISEE
Y953 VVAVLQPYIFVATVP
T958 QPYIFVATVPVIVAF
T1115 MPTEGKPTKSTKPYK
- gap
S1301 CLARSVLSKAKILLL
Y1363 EENKVRQYDSIQKLL
S1394 KLFPHRNSSKCKSKP
S1395 LFPHRNSSKCKSKPQ
T1410 IAALKEETEEEVQDT
  CFTR iso3  
S45 YQIPSVDSADNLSEK
S50 VDSADNLSEKLEREW
T94 FLYLGEVTKAVQPLL
S256 DQRAGKISERLVITS
T291 MIENLRQTELKLTRK
K420 KQNNNNRKTSNGDDS
S422 NNNNRKTSNGDDSLF
K447 VLKDINFKIERGQLL
S511 ENIIFGVSYDEYRYR
Y512 NIIFGVSYDEYRYRS
Y515 FGVSYDEYRYRSVIK
Y517 VSYDEYRYRSVIKAC
S549 GEGGITLSGGQRARI
T582 FGYLDVLTEKEIFER
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
S45 YQAPSADSADHLSEK
S50 ADSADHLSEKLEREW
T94 LLYLGEVTKAVQPVL
N256 DQRAAKINERLVITS
V291 MIENLREVELKMTRK
K420 QQSNGDRKHsSDENN
S422‑p SNGDRKHsSDENNVS
N447 VLKNINLNIEKGEML
S511 ENIIFGVSYDEYRYK
Y512 NIIFGVSYDEYRYKS
Y515 FGVSYDEYRYKSVVK
Y517 VSYDEYRYKSVVKAC
S549‑p GEGGVTLsGGQRARI
T582 FGYLDVFTEEQVFES
T604 NKTRILVTSKMEHLR
S605 KTRILVTSKMEHLRK
S641 QSLRPDFSSKLMGYD
S659‑p QFTEERRssILTETL
S660‑p FTEERRssILTETLR
S670‑p TETLRRFsVDDSSAP
P681 SSAPWSKPKQSFRQT
S684 PWSKPKQSFRQTGEV
S698‑p VGEKRKNsILNSFSS
S705 sILNSFSSVRKIsIV
S710‑p FSSVRKIsIVQKTPL
S723‑p PLCIDGEsDDLQEKR
S732‑p DLQEKRLsLVPDsEQ
S737‑p RLsLVPDsEQGEAAL
N748 EAALPRSNMIATGPT
S763‑p FPGRRRQsVLDLMTF
T769 QsVLDLMTFTPNSGS
T771 VLDLMTFTPNSGSSN
S785 NLQRTRTSIRKIsLV
S790‑p RTSIRKIsLVPQISL
S804 LNEVDVYSRRLsQDs
S808‑p DVYSRRLsQDsTLNI
S811‑p SRRLsQDsTLNITEE
Y1009 VVSALQPYIFLATVP
T1014 QPYIFLATVPGLVVF
T1172 QTEESMYTQIIKELP
S1183‑p KELPREGsSDVLVIK
S1358 CLARSVLSKAKIILL
Y1420 EESNVWQYDSLQALL
S1451 RFFQGRHSSKHKPRT
S1452 FFQGRHSSKHKPRTQ
T1467‑p ITALKEEtEEEVQET
  rat

 
S45 YQAPSSDSADHLSEK
S50 SDSADHLSEKLEREW
T94 LLYLGEVTKAVQPVL
N256 DKRAAKINERLVITS
E291 IIESLREEELKMTRR
K420 QLNNDDRKTSNGENH
S422 NNDDRKTSNGENHLS
N447 VLKNINLNIKKGEML
S511 ENIIFGVSYDEYRyK
Y512 NIIFGVSYDEYRyKS
Y515 FGVSYDEYRyKSVVK
Y517‑p VSYDEYRyKSVVKAC
S549‑p GEGGVTLsGGQRARI
T582 FGYLDVLTEEQIFES
T604 SKTRILVTSKMEQLK
S605 KTRILVTSKMEQLKK
S641 QSLRPDFSSKLMGYD
S659 QFTEERRSSILTETL
S660 FTEERRSSILTETLR
S670 TETLRRFSVDDASTT
A681 ASTTWNKAKQSFRQT
S684 TWNKAKQSFRQTGEF
S698 FGEKRKNSILSSFSS
S705 SILSSFSSVKKISIV
S710 FSSVKKISIVQKTPL
S723 PLSIEGESDDLQERR
S732 DLQERRLSLVPDSEH
S737 RLSLVPDSEHGEAAL
N748 EAALPRSNMITAGPT
S763 FPGRRRQSVLDLMTF
T769 QSVLDLMTFTPSSVS
T771 VLDLMTFTPSSVSSS
S785 SLQRTRASIRKISLA
S790 RASIRKISLAPRISL
S804 LKEEDIYSRRLsQDs
S808‑p DIYSRRLsQDsTLNI
S811‑p SRRLsQDsTLNITEE
Y1009 VVSALQPYIFLATVP
T1014 QPYIFLATVPGLAVF
T1172 QTEESICTKIMKELH
S1183 KELHSEDSPNALVIK
S1358 CLARSVLSKAKIILL
Y1420 EQGNVWQYESLQALL
S1451‑p KLFHGRHssKQKPRT
S1452‑p LFHGRHssKQKPRTQ
T1467 ITAVKEETEEEVQET
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