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Protein Page:
PROC (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PROC Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal dominant (THPH3). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal recessive (THPH4). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare. Belongs to the peptidase S1 family. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 3.4.21.69; Apoptosis
Chromosomal Location of Human Ortholog: 2q13-q14
Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi apparatus; Golgi lumen
Molecular Function: calcium ion binding; protein binding; serine-type endopeptidase activity
Biological Process: blood coagulation; cellular protein metabolic process; ER to Golgi vesicle-mediated transport; leukocyte migration; negative regulation of apoptosis; negative regulation of blood coagulation; negative regulation of coagulation; negative regulation of inflammatory response; peptidyl-glutamic acid carboxylation; post-translational protein modification; proteolysis; signal peptide processing
Disease: Thrombophilia Due To Protein C Deficiency, Autosomal Dominant; Thrombophilia Due To Protein C Deficiency, Autosomal Recessive
Reference #:  P04070 (UniProtKB)
Alt. Names/Synonyms: Activation peptide; Anticoagulant protein C; APC; Autoprothrombin IIA; Blood coagulation factor XIV; PC; PROC; PROC1; protein C; protein C (inactivator of coagulation factors Va and VIIIa); Vitamin K-dependent protein C; Vitamin K-dependent protein C heavy chain; Vitamin K-dependent protein C light chain
Gene Symbols: PROC
Molecular weight: 52,071 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
Select Structure to View Below

PROC

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K233‑ac QVVLLDSkkKLACGA
0 2 K234‑ac VVLLDSkkKLACGAV
  mouse

 
K233 QAILLDSKKKLACGG
K234 AILLDSKKKLACGGV
  rat

 
K234 QAILLDSKKKLACGG
K235 AILLDSKKKLACGGV
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