Could be involved in cell-cell interactions. Defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria (BFPP). BFPP is characterized by disorganized cortical lamination that is most severe in frontal cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Biological Process: angiogenesis; brain development; cell adhesion; cell migration; cell-cell signaling; cerebral cortex radial glia guided migration; layer formation in the cerebral cortex; negative regulation of cell proliferation; positive regulation of cell adhesion; positive regulation of Rho protein signal transduction; Rho protein signal transduction
Alt. Names/Synonyms: 7-transmembrane protein with no EGF-like N-terminal domains-1; BFPP; DKFZp781L1398; EGF-TM7-like; G protein-coupled receptor 56; G-protein coupled receptor 56; GPR56; Protein TM7XN1; TM7LN4; TM7XN1