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Protein Page:
PLCZ1 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PLCZ1 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Phospholipase; Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11
Chromosomal Location of Human Ortholog: 12p12.3
Cellular Component: cytosol; nucleus; perinuclear region of cytoplasm
Molecular Function: calcium ion binding; phosphoinositide phospholipase C activity; signal transducer activity
Biological Process: calcium ion transport; egg activation; inositol phosphate metabolic process; lipid catabolic process; multicellular organismal development
Reference #:  Q86YW0 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1; MGC149685; NYD-SP27; Phosphoinositide phospholipase C-zeta-1; phospholipase C, zeta 1; Phospholipase C-zeta-1; PI-phospholipase C zeta 1; PLC-zeta-1; PLCZ1; PLCzeta; Testis-development protein NYD-SP27; testis-development related NYD-SP27
Gene Symbols: PLCZ1
Molecular weight: 70,411 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below

PLCZ1

Protein Structure Not Found.


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Modification Sites and Domains  
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Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K344 KKKTRKLKIALALSD
0 1 K357 SDLVIYTKAEKFKSF
0 1 Y457 LDNGGSGYILKPHFL
  mouse

 
K381‑ac KKRKRKMkIAMALSD
K394‑ac SDLVIYTkAEKFRNF
Y494 LDNGGSGYILKPDIL
  rat

 
R380 KKKIRKLRVALALSD
K393 SDLVIYTKAEKFRNF
Y493‑p LDNGGSGyVLKPDFL
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