a nuclear transcription factor which binds DNA as a homodimer. Controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic gene, alpha 1-antitrypsin, apolipoprotein CIII, and transthyretin genes. May be essential for development of the liver, kidney and intestine. Mutations have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; DNA-binding; Transcription factor
Molecular Function: DNA binding; fatty acid binding; protein binding; protein homodimerization activity; receptor binding; transcription factor activity
Biological Process: blood coagulation; glucose homeostasis; lipid homeostasis; negative regulation of cell growth; negative regulation of cell proliferation; ornithine metabolic process; phospholipid homeostasis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of insulin secretion; regulation of lipid metabolic process; regulation of transcription from RNA polymerase II promoter; response to glucose stimulus; transcription initiation from RNA polymerase II promoter; xenobiotic metabolic process
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.