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Protein Page:
TRPA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TRPA1 Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. Belongs to the transient receptor (TC 1.A.4) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8q13
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: calcium channel activity; calcium-release channel activity; channel activity
Biological Process: ion transport; protein homotetramerization; response to organic substance; sensory perception of pain
Disease: Episodic Pain Syndrome, Familial, 1
Reference #:  O75762 (UniProtKB)
Alt. Names/Synonyms: ANKTM1; ankyrin-like with transmembrane domains 1; Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120; Transient receptor potential cation channel subfamily A member 1; transient receptor potential cation channel, subfamily A, member 1; TRPA1
Gene Symbols: TRPA1
Molecular weight: 127,501 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
Select Structure to View Below

TRPA1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S113‑p VEKNQIEsVKFLLSR
0 1 T304‑p GSVDIVNttDGCHET
0 1 T305‑p SVDIVNttDGCHETM
0 1 K337‑m1 SVGADINkIDSEGRS
0 3 S354‑p ILATASAsWNIVNLL
0 8 S363‑p NIVNLLLsKGAQVDI
0 1 K403‑ac FMQMQQIkELVMDED
0 1 S470‑p QRLLQDIsDTRLLNE
0 1 K503‑m1 KVVQLLLkkGALFLS
0 1 K504‑m1 VVQLLLkkGALFLSD
1 0 T673‑p PLEFTKKtPTQDVIY
0 1 T764‑p DHSEILDtTNSYLIK
  mouse

 
S114 AEKNQVESVKFLLSQ
A305 GSSDIVNAVDGNQET
V306 SSDIVNAVDGNQETL
S338 SVGADINSTDSEGRS
S355 ILATASASWNIVNLL
C364 NIVNLLLCKGAKVDI
K404 FMQMQHIKELVMDED
S471 QRLLQDISDTRLLNE
K504 KVVQLLLKKGALFLS
K505 VVQLLLKKGALFLSD
- under review  
T767 THEERIDTLNSFPIK
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