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Protein Page:
INHA (human)

Overview
INHA Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: cell soma; cytoplasm; extracellular region; photoreceptor inner segment; photoreceptor outer segment
Molecular Function: cytokine activity; growth factor activity; hormone activity; protein binding; protein heterodimerization activity; receptor binding; transforming growth factor beta receptor binding
Biological Process: cell cycle arrest; cell development; cell differentiation; cell surface receptor linked signal transduction; cell-cell signaling; erythrocyte differentiation; hemoglobin biosynthetic process; male gonad development; negative regulation of B cell differentiation; negative regulation of cell cycle; negative regulation of follicle-stimulating hormone secretion; negative regulation of interferon-gamma biosynthetic process; negative regulation of macrophage differentiation; negative regulation of phosphorylation; nervous system development; ovarian follicle development; positive regulation of follicle-stimulating hormone secretion; regulation of apoptosis; regulation of cell cycle; regulation of cell proliferation; regulation of MAPKKK cascade; response to external stimulus; signal transduction; skeletal development
Reference #:  P05111 (UniProtKB)
Alt. Names/Synonyms: A-inhibin subunit; INHA; Inhibin alpha chain; inhibin, alpha
Gene Symbols: INHA
Molecular weight: 39,670 Da
Basal Isoelectric point: 8.29  Predict pI for various phosphorylation states
Select Structure to View Below

INHA

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T204 LLRCPLCTCSARPEA
0 1 S206 RCPLCTCSARPEATP
0 1 A211 TCSARPEATPFLVAH
0 1 T212 CSARPEATPFLVAHT
0 1 S225‑p HTRTRPPsGGERARR
0 1 S233‑p GGERARRstPLMSWP
0 1 T234‑p GERARRstPLMSWPW
0 1 S244‑p MSWPWSPsALRLLQR
  mouse

 
S205‑p LLRCPLCsCsGRPEt
S207‑p RCPLCsCsGRPEttP
T212‑p sCsGRPEttPFLVAH
T213‑p CsGRPEttPFLVAHT
S226 HTRARAPSAGERARR
S234 AGERARRSTPSVPWP
T235 GERARRSTPSVPWPW
A245 VPWPWSPAALRLLQR
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