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Protein Page:
CX3CL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CX3CL1 The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Belongs to the intercrine delta family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q13
Cellular Component: cell surface; extracellular region; extracellular space; integral to membrane; plasma membrane
Molecular Function: CCR chemokine receptor binding; chemokine activity; CX3C chemokine receptor binding; integrin binding; protein binding; receptor binding
Biological Process: chemotaxis; cytokine and chemokine mediated signaling pathway; defense response; G-protein coupled receptor protein signaling pathway; immune response; integrin activation; leukocyte adhesive activation; leukocyte chemotaxis; leukocyte migration during inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of calcium-independent cell-cell adhesion; positive regulation of GTPase activity; positive regulation of inflammatory response
Reference #:  P78423 (UniProtKB)
Alt. Names/Synonyms: ABCD-3; C-X3-C motif chemokine 1; C3Xkine; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; CX3CL1; CXC3; CXC3C; FKN; Fractalkine; Neurotactin; NTN; NTT; Processed fractalkine; SCYD1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; Small-inducible cytokine D1; X3CL1
Gene Symbols: CX3CL1
Molecular weight: 42,203 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Select Structure to View Below

CX3CL1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T97‑p DRQAAALtRNGGTFE
0 1 T183‑ga QDGGPVGtELFRVPP
0 1 S225‑p APSTQDPsTQASTAS
0 1 S253‑ga RVWGQGQsPRPENSL
0 5 R262 RPENSLEREEMGPVP
0 1 T318‑ga AEEPIHAtMDPQRLG
0 1 K371 SLQGCPRKMAGEMAE
0 2 S389 YIPRSCGSNsYVLVP
0 2 S391‑p PRSCGSNsYVLVPV_
  mouse

 
T97 DHQAAALTKNGGKFE
I184 LTAKPQSIGSFEAAD
S225 SPSTTAPSPQVSTTS
D253 PPWVQGQDLSPEKSL
S262‑p SPEKSLGsEEINPVH
T316 IEEPIHATADPQKLS
K369‑ub SLQGCPRkMAGEMVE
S387‑p YVPRSCGsNsYVLVP
S389‑p PRSCGsNsYVLVPV_
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