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Protein Page:
PROKR2 (human)

Overview
PROKR2 Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Defects in PROKR2 are the cause of Kallmann syndrome type 3 (KAL3); also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. KAL3 patients have variable degrees of olfactory and reproductive dysfunction, but do not show any of the occasional clinical anomalies reported in Kallmann syndrome such as renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 20p12.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity
Biological Process: cell surface receptor linked signal transduction; circadian rhythm; G-protein coupled receptor protein signaling pathway
Disease: Hypogonadotropic Hypogonadism 3 With Or Without Anosmia
Reference #:  Q8NFJ6 (UniProtKB)
Alt. Names/Synonyms: dJ680N4.3; G protein-coupled receptor 73-like 1; G-protein coupled receptor 73-like 1; GPR73b; GPR73L1; GPRg2; KAL3; PK-R2; PKR2; Prokineticin receptor 2; PROKR2
Gene Symbols: PROKR2
Molecular weight: 43,996 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
Select Structure to View Below

PROKR2

Protein Structure Not Found.


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