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CaR a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3q13.33-q21.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: amino acid binding; calcium ion binding; G-protein coupled receptor activity; phosphoinositide phospholipase C activity; protein binding; protein homodimerization activity
Biological Process: anatomical structure morphogenesis; cellular calcium ion homeostasis; chemosensory behavior; detection of calcium ion; G-protein coupled receptor protein signaling pathway; ossification
Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1; Hypocalciuric Hypercalcemia, Familial, Type I
Reference #:  P41180 (UniProtKB)
Alt. Names/Synonyms: calcium-sensing receptor; CAR; CASR; EIG8; Extracellular calcium-sensing receptor; FHH; FIH; GPRC2A; HHC; HHC1; MGC138441; NSHPT; parathyroid Ca(2+)-sensing receptor 1; Parathyroid cell calcium-sensing receptor; PCAR1
Gene Symbols: CASR
Molecular weight: 120,675 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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