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PhosphoSitePlus
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Protein Page:
TTPA (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TTPA Binds alpha-tocopherol and enhances its transfer between separate membranes. Defects in TTPA are the cause of ataxia with isolated vitamin E deficiency (AVED). AVED is an autosomal recessive disease characterized by spinocerebellar degeneration. It causes ataxia and peripheral neuropathy that resembles Friedreich ataxia. AVED patients have markedly reduced plasma levels of vitamin E. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 8q12.3
Cellular Component: cytosol; late endosome
Molecular Function: phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; transporter activity; vitamin E binding
Biological Process: embryonic placenta development; intermembrane transport; intracellular pH reduction; lipid metabolic process; response to nutrient; response to pH; response to toxin; transport; vitamin E metabolic process; vitamin transport
Disease: Vitamin E, Familial Isolated Deficiency Of
Reference #:  P49638 (UniProtKB)
Alt. Names/Synonyms: Alpha-tocopherol transfer protein; Alpha-TTP; alphaTTP; ATTP; AVED; tocopherol (alpha) transfer protein; TPP1; TTP1; TTPA
Gene Symbols: TTPA
Molecular weight: 31,750 Da
Basal Isoelectric point: 7.17  Predict pI for various phosphorylation states
Select Structure to View Below

TTPA

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K71 DLAWRLLKNYYKWRA
0 1 Y100‑p IGLLKAGyHGVLRSR
0 1 K125 RIAHWDPKVFTAYDV
0 2 K178 ITPSVAKKIAAVLTD
0 1 K178 ITPSVAKKIAAVLTD
0 1 K190 LTDSFPLKVRGIHLI
0 1 K217 IKPFLTEKIKERIHM
  mouse

 
K71‑ub DLAWRLMkNYYKWRA
Y100 LGLLKAGYHGVLRSR
K125‑ub RIAYWDPkVFTAYDV
K178‑ac ITPSVAKkIAAVLTD
K178‑ub ITPSVAKkIAAVLTD
K190‑ub LTDSFPLkVRGIHLI
K217‑ub IKPFLTEkIKDRIHL
  rat

 
K71 DLAWRLMKNYYKWRA
Y100 LGLLKAGYHGVLRSR
K125 RISYWDPKVFTAYDV
K178‑ac ITPSVAKkIAAVVTD
K178 ITPSVAKKIAAVVTD
K190 VTDSFPLKVRGIHLI
K217 IKPFLTEKIKGRIHL
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