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Protein Page:
RORC (human)

RORC Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus
Molecular Function: oxysterol binding; protein binding; transcription factor activity
Biological Process: circadian regulation of gene expression; positive regulation of circadian rhythm; positive regulation of transcription, DNA-dependent; regulation of fat cell differentiation; regulation of steroid metabolic process; transcription initiation from RNA polymerase II promoter; xenobiotic metabolic process
Disease: Immunodeficiency 42
Reference #:  P51449 (UniProtKB)
Alt. Names/Synonyms: MGC129539; NR1F3; Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; Retinoid-related orphan receptor-gamma; RORC; RORG; RZR-GAMMA; RZRG; TOR
Gene Symbols: RORC
Molecular weight: 58,195 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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