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Protein Page:
RORC (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RORC Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus
Molecular Function: oxysterol binding; protein binding; transcription factor activity
Biological Process: circadian regulation of gene expression; positive regulation of circadian rhythm; positive regulation of transcription, DNA-dependent; regulation of fat cell differentiation; regulation of steroid metabolic process; transcription initiation from RNA polymerase II promoter; xenobiotic metabolic process
Disease: Immunodeficiency 42
Reference #:  P51449 (UniProtKB)
Alt. Names/Synonyms: MGC129539; NR1F3; Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; Retinoid-related orphan receptor-gamma; RORC; RORG; RZR-GAMMA; RZRG; TOR
Gene Symbols: RORC
Molecular weight: 58,195 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
Select Structure to View Below

RORC

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K37‑ac PCKICGDkSSGIHYG
0 1 K108 VKFGRMSKKQRDSLH
0 1 K120 SLHAEVQKQLQQRQQ
0 2 T136 QQEPVVKTPPAGAQG
0 2 S205‑p ASCHLEYsPERGKAE
0 1 T225‑p YSTGSQLtPDRCGLR
0 2 Y264‑p RSTPEAPyASLTEIE
0 1 S276‑p EIEHLVQsVCkSYRE
0 1 K279‑ub HLVQsVCkSYRETCQ
0 1 S339‑p VEFAKRLsGFMELCQ
1 0 K469 ILAKLPPKGKLRSLC
  RORC iso2  
K16 PCKICGDKSSGIHYG
K87 VKFGRMSKKQRDSLH
K99 SLHAEVQKQLQQRQQ
T115 QQEPVVKTPPAGAQG
S184 ASCHLEYSPERGKAE
T204 YSTGSQLTPDRCGLR
Y243 RSTPEAPYASLTEIE
S255 EIEHLVQSVCKSYRE
K258 HLVQSVCKSYRETCQ
S318 VEFAKRLSGFMELCQ
K448 ILAKLPPKGKLRSLC
  mouse

► Hide Isoforms
 
K37 PCKICGDKSSGIHYG
K108‑ac VKFGRMSkKQRDSLH
K120 SLHAEVQKQLQQQQQ
T134‑p QQEQVAKtPPAGSRG
S203‑p ASCHLEYsPERGKAE
T223 YSTDGQLTLGRCGLR
Y262 CSAPEVPYASLTDIE
N274 DIEYLVQNVCKSFRE
K277 YLVQNVCKSFRETCQ
S337 VEFAKRLSGFMELCQ
K467 LLAKLPPKGKLRSLC
  RORC iso2  
K16 PCKICGDKSSGIHYG
K87 VKFGRMSKKQRDSLH
K99 SLHAEVQKQLQQQQQ
T113 QQEQVAKTPPAGSRG
S182 ASCHLEYSPERGKAE
T202 YSTDGQLTLGRCGLR
Y241 CSAPEVPYASLTDIE
N253 DIEYLVQNVCKSFRE
K256 YLVQNVCKSFRETCQ
S316 VEFAKRLSGFMELCQ
K446‑ub LLAKLPPkGKLRSLC
  rat

 
K37 PCKICGDKSSGIHYG
K108 VKFGRMSKKQRDSLH
K120‑ac SLHAEVQkQLQQQQQ
T134 QREQVAKTPPAGSHG
S203 ASCHLEYSPERGKAE
T223 YSTDGQLTLGRRGLQ
Y254 CSAPEAPYASLTDIE
N266 DIEYLVQNVCKSYRE
K269 YLVQNVCKSYRETCQ
S329 VEFAKRLSGFMELCQ
K459 LLAKLPPKGKLRSLC
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