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Protein Page:
betaIG-H3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
betaIG-H3 Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Cell adhesion; Secreted; Extracellular matrix
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: extracellular matrix; extracellular region; extracellular space; plasma membrane; proteinaceous extracellular matrix; trans-Golgi network
Molecular Function: collagen binding; protein binding
Biological Process: angiogenesis; cellular protein metabolic process; extracellular matrix organization and biogenesis; negative regulation of cell adhesion
Disease: Corneal Dystrophy Of Bowman Layer, Type I; Corneal Dystrophy Of Bowman Layer, Type Ii; Corneal Dystrophy, Avellino Type; Corneal Dystrophy, Epithelial Basement Membrane; Corneal Dystrophy, Groenouw Type I; Corneal Dystrophy, Lattice Type I; Corneal Dystrophy, Lattice Type Iiia
Reference #:  Q15582 (UniProtKB)
Alt. Names/Synonyms: Beta ig-h3; beta-IG-H3; beta-IGH3; betaIG-H3; BGH3; BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; Kerato-epithelin; LCD1; RGD-CAP; RGD-containing collagen-associated protein; TGFBI; transforming growth factor, beta-induced, 68kDa; Transforming growth factor-beta-induced protein ig-h3
Gene Symbols: TGFBI
Molecular weight: 74,681 Da
Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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betaIG-H3

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 A9 ALFVRLLALALALAL
0 1 A15 LALALALALGPAATL
0 1 T21 LALGPAATLAGPAKs
0 1 S28‑p TLAGPAKsPyQLVLQ
0 1 S28‑ga TLAGPAKsPyQLVLQ
0 1 Y30‑p AGPAKsPyQLVLQHs
0 1 S37‑p yQLVLQHsRLRGRQH
0 1 T457‑p YHGQTLEtLGGKKLR
0 1 Y537‑p TLNREGVyTVFAPTN
0 1 S591‑p GALVRLKsLQGDKLE
0 4 S649‑p RGDELADsALEIFKQ
  mouse

 
T9‑p ALLMRLLtLALALsV
S15‑p LtLALALsVGPAGtL
T21‑p LsVGPAGtLAGPAKS
S28 tLAGPAKSPYQLVLQ
S28 tLAGPAKSPYQLVLQ
Y30 AGPAKSPYQLVLQHS
S37 YQLVLQHSRLRGRQH
T457 YSGQTLDTLGGKKLR
Y537 ILNREGVYTVFAPTN
S591 GALVRLKSLQGDKLE
S649 RGDELADSALEIFKQ
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