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Protein Page:
betaIG-H3 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
betaIG-H3 Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Extracellular matrix; Secreted; Cell adhesion
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: basement membrane; extracellular matrix; extracellular region; extracellular space; plasma membrane; proteinaceous extracellular matrix; trans-Golgi network
Molecular Function: collagen binding; extracellular matrix binding; integrin binding; protein binding
Biological Process: angiogenesis; cell adhesion; cell proliferation; cellular protein metabolic process; chondrocyte differentiation; extracellular matrix organization and biogenesis; negative regulation of cell adhesion; response to stimulus; visual perception
Disease: Corneal Dystrophy Of Bowman Layer, Type I; Corneal Dystrophy Of Bowman Layer, Type Ii; Corneal Dystrophy, Avellino Type; Corneal Dystrophy, Epithelial Basement Membrane; Corneal Dystrophy, Groenouw Type I; Corneal Dystrophy, Lattice Type I; Corneal Dystrophy, Lattice Type Iiia
Reference #:  Q15582 (UniProtKB)
Alt. Names/Synonyms: Beta ig-h3; beta-IG-H3; beta-IGH3; betaIG-H3; BGH3; BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; Kerato-epithelin; LCD1; RGD-CAP; RGD-containing collagen-associated protein; TGFBI; transforming growth factor, beta-induced, 68kDa; Transforming growth factor-beta-induced protein ig-h3
Gene Symbols: TGFBI
Molecular weight: 74,681 Da
Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

betaIG-H3

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S28‑p TLAGPAKsPyQLVLQ
0 1 S28‑ga TLAGPAKsPyQLVLQ
0 1 Y30‑p AGPAKsPyQLVLQHs
0 1 S37‑p yQLVLQHsRLRGRQH
0 1 T457‑p YHGQTLEtLGGKKLR
0 1 Y537‑p TLNREGVyTVFAPTN
0 1 S591‑p GALVRLKsLQGDKLE
0 3 S649‑p RGDELADsALEIFKQ
  mouse

 
S28 TLAGPAKSPyQLVLQ
S28 TLAGPAKSPyQLVLQ
Y30 AGPAKSPYQLVLQHS
S37 yQLVLQHSRLRGRQH
T457 YSGQTLDTLGGKKLR
Y537 ILNREGVYTVFAPTN
S591 GALVRLKSLQGDKLE
S649 RGDELADSALEIFKQ
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