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Protein Page:
DRD1 (human)

Overview
DRD1 a G-protein coupled receptor.One of the five types (D1 to D5) of receptors for dopamine. The most abundant dopamine receptor in the central nervous system. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Interacts with calcyon. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: caveola; cell soma; cytosol; dendritic shaft; endoplasmic reticulum membrane; integral to plasma membrane; nerve terminal; nonmotile primary cilium; nucleus; plasma membrane
Molecular Function: angiotensin receptor binding; ATPase binding; D3 dopamine receptor binding; dopamine binding; dopamine D1 receptor-like receptor activity; dopamine receptor activity; drug binding; G-protein alpha-subunit binding; protein binding; protein complex binding; protein heterodimerization activity; protein phosphatase binding
Biological Process: adenylate cyclase activation; adult walking behavior; astrocyte development; behavioral fear response; behavioral response to cocaine; calcium-mediated signaling; cellular response to insulin stimulus; cerebral cortex GABAergic interneuron migration; conditioned taste aversion; dentate gyrus development; dopamine metabolic process; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, phospholipase C activating pathway; dopamine transport; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; generation of action potential; glucose import; grooming behavior; habituation; learning; maternal behavior; mating behavior; memory; negative regulation of cell migration; negative regulation of circadian sleep/wake cycle, sleep; negative regulation of protein kinase activity; operant conditioning; orbitofrontal cortex development; peristalsis; positive regulation of cAMP biosynthetic process; positive regulation of cell migration; positive regulation of membrane potential; positive regulation of potassium ion transport; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of synaptic transmission, glutamatergic; prepulse inhibition; protein import into nucleus; regulation of dopamine metabolic process; regulation of dopamine uptake; regulation of long-term neuronal synaptic plasticity; regulation of vasoconstriction; response to activity; response to amino acid stimulus; response to amphetamine; response to drug; response to estradiol stimulus; response to ethanol; response to food; response to morphine; response to nicotine; response to retinoic acid; sensitization; social behavior; striatum development; synaptic transmission, dopaminergic; synaptogenesis; thermoregulation; transmission of nerve impulse; vasodilation; visual learning
Reference #:  P21728 (UniProtKB)
Alt. Names/Synonyms: D(1A) dopamine receptor; DADR; Dopamine D1 receptor; dopamine receptor D1; DRD1; DRD1A
Gene Symbols: DRD1
Molecular weight: 49,293 Da
Basal Isoelectric point: 8.64  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Select Structure to View Below

DRD1

Protein Structure Not Found.


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Sites Implicated In
receptor desensitization, altered: T360‑p
receptor internalization, altered: T360‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S56‑p IRFRHLRsKVTNFFV
0 1 T136‑p FRYERKMtPKAAFIL
1 0 P256 KPVECSQPESSFKMS
1 0 S258 VECSQPESSFKMSFK
1 0 S259 ECSQPESSFKMSFKR
1 0 T268 KMSFKRETKVLKTLS
1 0 T360‑p ATNNAIEtVSINNNG
2 0 S421 EKLSPALSVILDYDT
1 0 T428 SVILDYDTDVSLEKI
1 0 S431 LDYDTDVSLEKIQPI
0 1 N441 KIQPITQNGQHPT__
0 1 T446 TQNGQHPT_______
  mouse

 
S55 IRFRHLRSKVTNFFV
T135 FQYERKMTPKAAFIL
S256 NPVECSQSESSFKMS
S258 VECSQSESSFKMSFK
S259 ECSQSESSFKMSFKR
T268 KMSFKRETKVLKTLS
T360 TTNNAIETVSINNNG
S421‑p EKLSPALsVILDYDT
T428 sVILDYDTDVSLEKI
S431 LDYDTDVSLEKIQPV
S441‑p KIQPVTHsGQHSt__
T446‑p THsGQHSt_______
  rat

 
S55 IRFRHLRSKVTNFFV
T135 FQYERKMTPKAAFIL
S256‑p NPVECAQsEssFKMS
S258‑p VECAQsEssFKMSFK
S259‑p ECAQsEssFKMSFKR
T268‑p KMSFKREtKVLKTLS
T360 TTNNAIETVSINNNG
S421‑p EKLSPALsVILDYDt
T428‑p sVILDYDtDVsLEKI
S431‑p LDYDtDVsLEKIQPV
S441 KIQPVTHSGQHST__
T446 THSGQHST_______
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