Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
DRD1 (human)

Overview
DRD1 a G-protein coupled receptor.One of the five types (D1 to D5) of receptors for dopamine. The most abundant dopamine receptor in the central nervous system. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Interacts with calcyon. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: integral to plasma membrane; nonmotile primary cilium; plasma membrane
Molecular Function: dopamine binding; dopamine D1 receptor-like receptor activity; dopamine receptor activity; protein binding
Biological Process: adenylate cyclase activation; adult walking behavior; cerebral cortex GABAergic interneuron migration; dopamine metabolic process; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, phospholipase C activating pathway; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; learning; mating behavior; positive regulation of cAMP biosynthetic process; positive regulation of cell migration; positive regulation of potassium ion transport; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of synaptic transmission, glutamatergic; prepulse inhibition; regulation of dopamine uptake; response to drug; synaptic transmission, dopaminergic; synaptogenesis; transmission of nerve impulse; visual learning
Reference #:  P21728 (UniProtKB)
Alt. Names/Synonyms: D(1A) dopamine receptor; DADR; Dopamine D1 receptor; dopamine receptor D1; DRD1; DRD1A
Gene Symbols: DRD1
Molecular weight: 49,293 Da
Basal Isoelectric point: 8.64  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Select Structure to View Below

DRD1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
receptor desensitization, altered: T360‑p
receptor internalization, altered: T360‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S56‑p IRFRHLRsKVTNFFV
0 1 T136‑p FRYERKMtPKAAFIL
1 0 P256 KPVECSQPESSFKMS
1 0 S258 VECSQPESSFKMSFK
1 0 S259 ECSQPESSFKMSFKR
1 0 T268 KMSFKRETKVLKTLS
1 0 T360‑p ATNNAIEtVSINNNG
2 0 S421 EKLSPALSVILDYDT
1 0 T428 SVILDYDTDVSLEKI
1 0 S431 LDYDTDVSLEKIQPI
0 1 N441 KIQPITQNGQHPT__
0 1 T446 TQNGQHPT_______
  mouse

 
S55 IRFRHLRSKVTNFFV
T135 FQYERKMTPKAAFIL
S256 NPVECSQSESSFKMS
S258 VECSQSESSFKMSFK
S259 ECSQSESSFKMSFKR
T268 KMSFKRETKVLKTLS
T360 TTNNAIETVSINNNG
S421‑p EKLSPALsVILDYDT
T428 sVILDYDTDVSLEKI
S431 LDYDTDVSLEKIQPV
S441‑p KIQPVTHsGQHSt__
T446‑p THsGQHSt_______
  rat

 
S55 IRFRHLRSKVTNFFV
T135 FQYERKMTPKAAFIL
S256‑p NPVECAQsEssFKMS
S258‑p VECAQsEssFKMSFK
S259‑p ECAQsEssFKMSFKR
T268‑p KMSFKREtKVLKTLS
T360 TTNNAIETVSINNNG
S421‑p EKLSPALsVILDYDt
T428‑p sVILDYDtDVsLEKI
S431‑p LDYDtDVsLEKIQPV
S441 KIQPVTHSGQHST__
T446 THSGQHST_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.