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Protein Page:
NuMA-1 (human)

NuMA-1 a coiled-coil nuclear protein that is required to establish and maintain mammalian spindle poles. Dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident. Two human splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: cell cortex; centrosome; cytoplasm; cytosol; nucleoplasm; nucleus; spindle; spindle microtubule; spindle pole
Molecular Function: protein binding; structural molecule activity
Biological Process: nuclear organization and biogenesis
Disease: Acute Promyelocytic Leukemia
Reference #:  Q14980 (UniProtKB)
Alt. Names/Synonyms: centrophilin stabilizes mitotic spindle in mitotic cells; Nuclear mitotic apparatus protein 1; NUMA; NuMA protein; NUMA1; SP-H antigen; structural nuclear protein
Gene Symbols: NUMA1
Molecular weight: 238,260 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
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