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Protein Page:
Rab7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Rab7 a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; late endosome; late endosome membrane; lipid particle; lysosomal membrane; lysosome; melanosome membrane; phagocytic vesicle; phagocytic vesicle membrane; pre-autophagosomal structure membrane; retromer complex; terminal button; vacuolar membrane
Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding; Rac GTPase binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; bone resorption; early endosome to late endosome transport; endocytosis; endosome to lysosome transport; epidermal growth factor ligand processing; positive regulation of protein catabolic process; positive regulation of viral reproduction; protein targeting to lysosome; protein to membrane docking; protein transport; release of virus from host; retrograde transport, endosome to Golgi; small GTPase mediated signal transduction
Disease: Charcot-marie-tooth Disease, Axonal, Type 2b
Reference #:  P51149 (UniProtKB)
Alt. Names/Synonyms: FLJ20819; PRO2706; RAB7; RAB7, member RAS oncogene family; RAB7A; RAB7A, member RAS oncogene family; Ras-associated protein RAB7; Ras-related protein Rab-7a
Gene Symbols: RAB7A
Molecular weight: 23,490 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Rab7

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S72‑p, Y183‑p
molecular association, regulation: S72‑p, Y183‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 S17‑p KVIILGDsGVGKTSL
0 1 K32 MNQYVNKKFSNQykA
0 1 K32‑ub MNQYVNKkFSNQykA
0 11 Y37‑p NKkFSNQykAtIGAD
1 9 K38‑ub KkFSNQykAtIGADF
0 1 T40‑p FSNQykAtIGADFLT
0 1 K48‑ub IGADFLTkEVMVDDR
2 58 S72‑p AGQERFQsLGVAFYR
0 1 K97‑ub VTAPNTFkTLDsWRD
0 1 S101‑p NTFkTLDsWRDEFLI
0 1 S111‑p DEFLIQAsPRDPENF
0 4 K126‑ub PFVVLGNkIDLENRQ
0 1 K137‑ub ENRQVATkRAQAWCY
0 1 K157‑ub PYFETSAkEAINVEQ
0 6 T168‑p NVEQAFQtIARNALk
0 1 K175‑ub tIARNALkQEtEVEL
0 3 T178‑p RNALkQEtEVELyNE
1 248 Y183‑p QEtEVELyNEFPEPI
1 45 K191‑ub NEFPEPIkLDkNDRA
1 13 K194‑ub PEPIkLDkNDRAKAs
0 1 S201‑p kNDRAKAsAEsCsC_
0 1 S204‑p RAKAsAEsCsC____
0 1 S206‑p KAsAEsCsC______
  mouse

 
S17‑p KVIILGDsGVGKTSL
K32 MNQYVNKKFSNQYkA
K32 MNQYVNKKFSNQYkA
Y37 NKKFSNQYkATIGAD
K38‑ub KKFSNQYkATIGADF
T40 FSNQYkATIGADFLT
K48 IGADFLTKEVMVDDR
S72‑p AGQERFQsLGVAFYR
K97 VTAPNTFKTLDSWRD
S101 NTFKTLDSWRDEFLI
S111 DEFLIQASPRDPENF
K126‑ub PFVVLGNkIDLENRQ
K137 ENRQVATKRAQAWCY
K157 PYFETSAKEAINVEQ
T168 NVEQAFQTIARNALK
K175 TIARNALKQETEVEL
T178 RNALKQETEVELyNE
Y183‑p QETEVELyNEFPEPI
K191‑ub NEFPEPIkLDkNDRA
K194‑ub PEPIkLDkNDRAKAS
S201 kNDRAKASAESCSC_
S204 RAKASAESCSC____
S206 KASAESCSC______
  rat

 
S17 KVIILGDSGVGKTSL
K32‑ac MNQYVNKkFSNQYKA
K32 MNQYVNKKFSNQYKA
Y37 NKkFSNQYKATIGAD
K38 KkFSNQYKATIGADF
T40 FSNQYKATIGADFLT
K48 IGADFLTKEVMVDDR
S72‑p AGQERFQsLGVAFYR
K97 VTAPNTFKTLDSWRD
S101 NTFKTLDSWRDEFLI
S111 DEFLIQASPRDPENF
K126 PFVVLGNKIDLENRQ
K137 ENRQVATKRAQAWCY
K157 PYFETSAKEAINVEQ
T168 NVEQAFQTIARNALK
K175 TIARNALKQETEVEL
T178 RNALKQETEVELyNE
Y183‑p QETEVELyNEFPEPI
K191 NEFPEPIKLDKNERA
K194 PEPIKLDKNERAKAS
S201 KNERAKASAESCSC_
S204 RAKASAESCSC____
S206 KASAESCSC______
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