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Bcl-xL (rat)

Overview Bcl-xL an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB. Protein type: Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Chromosomal Location of Human Ortholog: 3q41 Cellular Component: centrosome; coated pit; cytoplasm; cytosol; endoplasmic reticulum; intracellular; membrane; mitochondrial envelope; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; synaptic vesicle membrane Molecular Function: BH domain binding; BH3 domain binding; caspase inhibitor activity; clathrin binding; GTPase binding; identical protein binding; protein binding; protein complex binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; transcription factor binding Biological Process: aging; apoptosis; cell proliferation; cellular process regulating host cell cycle in response to virus; cerebral cortex development; DNA damage response, signal transduction resulting in induction of apoptosis; fertilization; germ cell development; growth; in utero embryonic development; male gonad development; mitotic cell cycle checkpoint; negative regulation of apoptosis; negative regulation of neuron apoptosis; neuron apoptosis; ovarian follicle development; positive regulation of apoptosis; positive regulation of cell proliferation; regulation of apoptosis; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; release of cytochrome c from mitochondria; response to cycloheximide; response to cytokine stimulus; response to drug; response to electrical stimulus; response to hydrogen peroxide; response to hypoxia; response to inorganic substance; response to lead ion; response to lipopolysaccharide; response to organic cyclic substance; response to organic nitrogen; response to oxidative stress; response to peptide hormone stimulus; response to radiation; response to virus; spermatogenesis; suppression by virus of host apoptosis Reference #:  P53563 (UniProtKB) Alt. Names/Synonyms: Apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B2CL1; Bcl-2-like protein 1; bcl-X; Bcl-xl; Bcl2-L-1; Bcl2-like 1; Bcl2l; Bcl2l1; Bclx; Blc2l Gene Symbols: Bcl2l1 Molecular weight: 26,158 Da Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Bcl-xL 1AF3 - A=1-196 (rat) 4QNQ - F/A/J/K/E/B/H/C/D/I/G/L=1-233 (rat) 1BXL - A=1-209 (human) 1G5J - A=1-209 (human) 1LXL - A=1-209 (human) 1MAZ - A=1-209 (human) 1R2D - A=1-211 (human) 1R2E - A=1-211 (human) 1R2G - A=1-211 (human) 1R2H - A=1-211 (human) 1R2I - A=1-211 (human) 1YSG - A=1-209 (human) 1YSI - A=1-209 (human) 1YSN - A=1-209 (human) 2B48 - A=1-211 (human) 2LP8 - A=1-209 (human) 2LPC - A=85-209 (human) 2M03 - A=1-209 (human) 2M04 - A=1-209 (human) 2ME8 - A=1-209 (human) 2ME9 - A=1-209 (human) 2MEJ - A=1-198 (human) 2O1Y - A=1-209 (human) 2O2M - A=73-196 (human) 2O2N - A=73-196 (human) 2P1L - A/C/E/G=1-209 (human) 2YJ1 - A/C=83-209 (human) 2YQ6 - A=1-209 (human) 2YQ7 - A=1-209 (human) 2YXJ - A/B=1-209 (human) 3CVA - X=1-211 (human) 3FDL - A=1-209 (human) 3FDM - A/C/B=83-209 (human) 3INQ - A/B=83-209 (human) 3IO8 - A/C=1-209 (human) 3PL7 - A/B=1-209 (human) 3QKD - A/B=1-209 (human) 3R85 - A/B/C/D=1-197 (human) 3SP7 - A=85-209 (human) 3SPF - A=85-209 (human) 3WIZ - A/B=85-209 (human) 3ZK6 - A/B=81-209 (human) 3ZLN - A=85-209 (human) 3ZLO - A=85-209 (human) 3ZLR - A/B=83-209 (human) 4A1U - A=83-209 (human) 4A1W - A/D/C/B=83-209 (human) 4AQ3 - A/B/C/D/E/F=29-44 (human) 4BPK - A/B=83-209 (human) 4C52 - A/B=83-209 (human) 4C5D - A/B=83-209 (human) 4CIN - A/B=83-209 D/C=79-102 (human) 4EHR - A=1-209 (human) 4HNJ - A/B=1-209 (human) 4IEH - A=29-44 (human) 4PPI - A=1-209 (human) 4QVE - A=1-209 (human) 4QVF - A=1-209 (human) 4QVX - A/B=83-209 (human) 4TUH - F/A/E/B/H/C/D/G=83-209 (human) 4Z9V - A/B=83-208 (human) 5AGW - A/B=29-44 (human) 5AGX - A/B=29-44 (human) 5B1Z - A/B=1-209 (human) 5C3G - A=83-209 (human) 5FMJ - A=83-209 (human) 5FMK - A=83-209 (human) 1PQ0 - A=1-196 (mouse) 1PQ1 - A=1-196 (mouse) 2BZW - A=1-211 (mouse) 3IHC - A=1-196 (mouse) 3IHD - A=1-196 (mouse) 3IHE - A=1-196 (mouse) 3IHF - A/D/C/B=1-196 (mouse) 3IIG - A=1-196 (mouse) 3IIH - A=1-196 (mouse) 3ILB - A/N=1-196 (mouse) 3ILC - A=1-196 (mouse) 4YJ4 - A=1-196 (mouse) 4YK9 - F/A=2-196 (mouse) 5C3G - A=1-26 (mouse)

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