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Protein Page:
WRAP53 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
WRAP53 a protein of unknown function. Contains 6 WD40 domains, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: Cajal body; cytoplasm; nucleus; telomerase holoenzyme complex
Molecular Function: chaperone binding; protein binding; protein complex binding; RNA binding
Biological Process: positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; telomere formation via telomerase; telomere maintenance via telomerase
Disease: Dyskeratosis Congenita, Autosomal Recessive, 3
Reference #:  Q9BUR4 (UniProtKB)
Gene Symbols: WRAP53
Molecular weight: 59,309 Da
Basal Isoelectric point: 4.46  Predict pI for various phosphorylation states
Select Structure to View Below

WRAP53

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S16‑p LAPDCCPsDQDPAPA
0 13 S26‑p DPAPAHPsPHAsPMN
0 24 S30‑p AHPsPHAsPMNKNAD
0 23 S54‑p RGDPPRLsPDPVAGS
0 3 S64‑p PVAGSAVsQELREGD
0 1 T77‑p GDPVSLStPLEtEFG
0 1 T81‑p SLStPLEtEFGsPsE
0 19 S85‑p PLEtEFGsPsELsPR
0 5 S87‑p EtEFGsPsELsPRIE
0 31 S90‑p FGsPsELsPRIEEQE
0 1 T102‑p EQELSENtsLPAEEA
0 4 S103‑p QELSENtsLPAEEAN
0 6 S112‑p PAEEANGsLsEEEAN
0 8 S114‑p EEANGsLsEEEANGP
0 1 S133‑p GKAMEDTsGEPAAED
0 1 S160‑p LPRFLSGsWSEFSTQ
0 1 K176‑ub ENFLKGCkWAPDGSC
0 1 Y211‑p HEGEQVEyAEMVPVL
0 1 S267‑p FTGELRAsFRAYNHL
0 1 S304 NRTVRVFSTARPGRD
0 1 T305 RTVRVFSTARPGRDC
0 1 K388‑ub RFFSGARkDAELLCW
0 9 T489‑p QRVFPEPtEsGDEGE
0 31 S491‑p VFPEPtEsGDEGEEL
  mouse

 
P16 LAPDSLPPDLAPAPV
- gap
S27‑p PAPVPQGsPAEKNTD
T52 DDQPQLATDPVASLV
S61 PVASLVVSQELQQGD
V70 ELQQGDSVPLEVEFN
V74 GDSVPLEVEFNTSSE
T78 PLEVEFNTSSELSPG
S80 EVEFNTSSELSPGIE
S83 FNTSSELSPGIEEQD
A95 EQDVSEHASLPGEET
S96 QDVSEHASLPGEETN
- gap
- gap
S117 GEATEGVSEERAEVD
S144 VPRYLSGSWSEFSTR
K160 ENFLKGCKWAPDGSC
Y195 SEQEQVDYAEMVPVL
S251 FTGELRASFRAYNHL
S288‑p NRTVRVFstSRPGRD
T289‑p RTVRVFstSRPGRDC
K372 LFFSGARKDAELLCW
T474 QRVFPEPTNSGDEGE
S476 VFPEPTNSGDEGELE
  rat

 
S16 LAPDSLPSDLVPAPV
- gap
S27‑p PAPVLQAsPADKNTD
T52 DDQLQVATDAVASSV
S61 AVASSVVSQELQQGD
A70 ELQQGDSAPLEVEFN
V74 GDSAPLEVEFNISSE
I78 PLEVEFNISSELSPR
S80 EVEFNISSELSPRIE
S83 FNISSELSPRIEEQE
A95 EQEVPENASLPVEET
S96 QEVPENASLPVEETN
- gap
- gap
S117 GEAMEGVSEEPAAVD
S144 VPQYLSGSWSEFSTR
K160 ENFLKGCKWAPDGSC
Y195 SESEQVDYAEMVPVL
S251 FTGELRASFRAYNHL
S288 NRTVRVFSTSRPGRD
T289 RTVRVFSTSRPGRDC
K372 LFFSGARKDAELLCW
T474 QRMFPEPTNsGDEGE
S476‑p MFPEPTNsGDEGEPE
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