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Protein Page:
NPC1 (human)

Overview
NPC1 Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals. Defects in NPC1 are the cause of Niemann-Pick disease type C1 (NPC1). A lysosomal storage disorder that affects the viscera and the central nervous system. It is due to defective intracellular processing and transport of low-density lipoprotein derived cholesterol. It causes accumulation of cholesterol in lysosomes, with delayed induction of cholesterol homeostatic reactions. Niemann-Pick disease type C1 has a highly variable clinical phenotype. Clinical features include variable hepatosplenomegaly and severe progressive neurological dysfunction such as ataxia, dystonia and dementia. The age of onset can vary from infancy to late adulthood. An allelic variant of Niemann-Pick disease type C1 is found in people with Nova Scotia ancestry. Patients with the Nova Scotian clinical variant are less severely affected. Belongs to the patched family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component: endoplasmic reticulum; extracellular region; integral to membrane; integral to plasma membrane; lysosomal membrane; lysosome; membrane; nuclear envelope; perinuclear region of cytoplasm
Molecular Function: cholesterol binding; protein binding; receptor activity; sterol transporter activity; transmembrane receptor activity
Biological Process: autophagy; bile acid metabolic process; cholesterol efflux; cholesterol homeostasis; cholesterol transport; entry of virus into host cell; lipid raft organization and biogenesis; lysosomal transport; protein amino acid glycosylation
Disease: Niemann-pick Disease, Type C1
Reference #:  O15118 (UniProtKB)
Alt. Names/Synonyms: FLJ98532; Niemann-Pick C1 protein; Niemann-Pick disease, type C1; NPC; NPC1
Gene Symbols: NPC1
Molecular weight: 142,167 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
Select Structure to View Below

NPC1

Protein Structure Not Found.
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