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Protein Page:
LGR5 (human)

Overview
LGR5 a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of cycling, long-lived and multipotent adult stem cell populations. Target gene of Wnt signaling. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Intestinal Lgr5+ stem cells give rise throughout life to proliferation of cells in crypts, which migrate along the crypt-villus axis, differentiating into five main cell types. Wnt signaling plays a crucial role in the proliferation and differentiation of these crypt epithelial cells. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12q22-q23
Cellular Component: integral to plasma membrane; plasma membrane; trans-Golgi network membrane
Molecular Function: G-protein coupled receptor activity; protein binding; transmembrane receptor activity
Reference #:  O75473 (UniProtKB)
Alt. Names/Synonyms: FEX; G protein-coupled receptor 49; G protein-coupled receptor 67; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; GPR49; GPR67; GRP49; HG38; leucine-rich repeat-containing G protein-coupled receptor 5; Leucine-rich repeat-containing G-protein coupled receptor 5; LGR5; MGC117008; orphan G protein-coupled receptor HG38
Gene Symbols: LGR5
Molecular weight: 99,998 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Select Structure to View Below

LGR5

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y114‑p KGAFTGLySLKVLML
0 1 S590‑p FRSPLYIsPIKLLIG
0 1 S721‑p PLPFGEPstMGYMVA
0 1 T722‑p LPFGEPstMGYMVAL
0 1 T842‑p RKQTYVWtRsKHPsL
1 1 S844‑p QTYVWtRsKHPsLMs
1 1 S848‑p WtRsKHPsLMsINsD
1 0 S851‑p sKHPsLMsINsDDVE
1 1 S854‑p PsLMsINsDDVEKQs
1 0 S861‑p sDDVEKQsCDsTQAL
1 0 S864‑p VEKQsCDsTQALVTF
  mouse

 
H114 KGAFTGLHSLKVLML
S590 FRTPLYISSIKLLIG
S721 PLPFGEPSTTGYMVA
T722 LPFGEPSTTGYMVAL
M842 GKHTRFWMRSKHASL
S844 HTRFWMRSKHASLLS
S848 WMRSKHASLLSINsD
S851 SKHASLLSINsDDVE
S854‑p ASLLSINsDDVEKRS
S861 sDDVEKRSCESTQAL
S864 VEKRSCESTQALVSF
  rat

 
H114 KGAFAGLHSLKVLML
S590 FRTPLYISSIKLLIG
S721 PLPFGEPSTTGYMVA
T722 LPFGEPSTTGYMVAL
T842 GKQTRFWTRAKHPSL
A844 QTRFWTRAKHPSLLS
S848 WTRAKHPSLLSINSD
S851 AKHPSLLSINSDDVE
S854 PSLLSINSDDVEKRS
S861 SDDVEKRSCDSTQAL
S864 VEKRSCDSTQALVSF
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