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BIM
a pro-apoptotic member of the BCL-2 protein family. Interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies in the mouse suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. Nineteen alternatively spliced transcript variants of this gene have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis |
| Chromosomal Location of Human Ortholog: 3q36 |
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Cellular Component: cytoplasm; cytoplasmic dynein complex; cytosol; extrinsic to membrane; intracellular membrane-bound organelle; microtubule; mitochondrion
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Molecular Function: microtubule binding; protein binding; protein heterodimerization activity
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Biological Process: B cell apoptosis; B cell homeostasis; brain development; caspase activation; cell-matrix adhesion; cellular process regulating host cell cycle in response to virus; DNA damage response, signal transduction resulting in induction of apoptosis; ear development; in utero embryonic development; kidney development; leukocyte homeostasis; lumen formation; lymphocyte homeostasis; male gonad development; mammary gland development; meiosis I; myeloid cell homeostasis; odontogenesis of dentine-containing teeth; pigmentation during development; positive regulation of apoptosis; positive regulation of apoptosis by virus; positive regulation of caspase activity; positive regulation of cell cycle; positive regulation of neuron apoptosis; positive regulation of protein homooligomerization; post-embryonic development; post-embryonic organ morphogenesis; regulation of apoptosis; regulation of organ growth; regulation of pigmentation during development; spermatogenesis; spleen development; T cell homeostasis; thymus development
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Reference #:
O88498
(UniProtKB)
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Alt. Names/Synonyms: B2L11; Bcl-2 related apoptotic gene product BimL; Bcl-2-like protein 11; Bcl-2-related ovarian death protein; Bcl2-interacting mediator of cell death; Bcl2-L-11; BCL2-like 11 (apoptosis facilitator); Bcl2l11; Bim; BimL; Bod
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Gene Symbols: Bcl2l11
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Molecular weight:
22,056 Da
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Basal Isoelectric point:
6.1
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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Growth And Differentiation Control by MAPKs
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Inhibition of Apoptosis
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Mitochondrial Control of Apoptosis
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PI3K/Akt Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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