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Protein Page:
CD3E (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD3E a T cell surface glycoprotein that is a component of the T cell antigen receptor. The recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Contains 1 immunoglobulin-like domain and 1 ITAM domain. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: alpha-beta T cell receptor complex; external side of plasma membrane; immunological synapse; integral to membrane; intercellular junction; membrane; plasma membrane; T cell receptor complex
Molecular Function: protein binding; protein heterodimerization activity; SH3 domain binding; signal transducer activity; transmembrane receptor activity
Biological Process: cell surface receptor linked signal transduction; immune system process; lymphocyte activation; negative regulation of smoothened signaling pathway; negative thymic T cell selection; positive regulation of alpha-beta T cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of interferon-gamma production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell activation; positive regulation of T cell anergy; positive regulation of T cell proliferation; response to nutrient; T cell costimulation; T cell receptor signaling pathway
Reference #:  P22646 (UniProtKB)
Alt. Names/Synonyms: AI504783; CD3; CD3 antigen, epsilon polypeptide; Cd3e; CD3epsilon; OTTMUSP00000018104; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3e
Gene Symbols: Cd3e
Molecular weight: 21,393 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD3E

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y170‑p, Y181‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 - gap
0 1 V68 QKHDKHLVLQDFSEV
0 4 K159‑ub SRPRGQNkERPPPVP
4 384 Y170‑p PPVPNPDyEPIRKGQ
4 400 Y181‑p RKGQRDLySGLNQRA
0 19 S182 KGQRDLySGLNQRAV
  human

 
S77‑p EDDKNIGsDEDHLsL
S83‑p GsDEDHLsLKEFSEL
K177‑ub GRQRGQNkERPPPVP
Y188‑p PPVPNPDyEPIRKGQ
Y199‑p RKGQRDLysGLNQRR
S200‑p KGQRDLysGLNQRRI
  rat

 
- gap
V63 DKNEKHLVLEDFSEV
K158 GKAQGQNKERPPPVP
Y169 PPVPNPDYEPIRKGQ
Y180 RKGQRDLYSGLNQRA
S181 KGQRDLYSGLNQRAV
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