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Protein Page:
GJB6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

GJB6 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Beta-type (group I) subfamily. A connexon is composed of a hexamer of connexins. Interacts with CNST.
Protein type: Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: cell junction
Disease: Clouston Syndrome; Deafness, Autosomal Dominant 3b; Deafness, Autosomal Recessive 1a; Deafness, Autosomal Recessive 1b; Deafness, X-linked 2
Reference #:  O95452 (UniProtKB)
Alt. Names/Synonyms: connexin 30; connexin-30; CX30; DFNA3; DFNA3B; DFNB1B; ectodermal dysplasia 2, hidrotic (Clouston syndrome); ED2; EDH; gap junction beta-6 protein; gap junction protein, beta 6; gap junction protein, beta 6, 30kDa; GJB6; HED
Gene Symbols: GJB6
Molecular weight: 30,387 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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