a small GTPase protein of the Ras family. Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Mutations are implicated in a variety of human tumors. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; G protein, monomeric, Ras; G protein; Oncoprotein; G protein, monomeric
Molecular Function: GTP binding; GTPase activity; nucleotide binding; protein binding; protein C-terminus binding
Biological Process: apoptosis; cell aging; cell cycle arrest; cell proliferation; defense response to protozoan; endocytosis; mitotic cell cycle checkpoint; negative regulation of cell proliferation; negative regulation of neuron apoptosis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of GTPase activity; positive regulation of interferon-gamma production; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of transcription from RNA polymerase II promoter; protein heterooligomerization; Ras protein signal transduction; regulation of long-term neuronal synaptic plasticity; signal transduction; small GTPase mediated signal transduction; T cell receptor signaling pathway; T-helper 1 type immune response
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.