Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
HRas (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HRas a small GTPase protein of the Ras family. Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Mutations are implicated in a variety of human tumors. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; Oncoprotein; G protein, monomeric, Ras; Motility/polarity/chemotaxis
Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; membrane; plasma membrane
Molecular Function: GTP binding; GTPase activity; nucleotide binding; protein binding; protein C-terminus binding
Biological Process: apoptosis; cell aging; cell cycle arrest; cell proliferation; defense response to protozoan; endocytosis; mitotic cell cycle checkpoint; negative regulation of cell proliferation; negative regulation of neuron apoptosis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of GTPase activity; positive regulation of interferon-gamma production; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of transcription from RNA polymerase II promoter; protein heterooligomerization; Ras protein signal transduction; regulation of long-term neuronal synaptic plasticity; signal transduction; small GTPase mediated signal transduction; T cell receptor signaling pathway; T-helper 1 type immune response
Reference #:  Q61411 (UniProtKB)
Alt. Names/Synonyms: c-H-ras; c-Ha-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-rasHa; GTPase HRas; GTPase HRas, N-terminally processed; H-Ras; H-ras; H-ras 1 protein; H-Ras-1; Ha-ras; Harvey rat sarcoma virus oncogene 1; Harvey-ras; Hras; Hras-1; Hras1; Kras2; OTTMUSP00000017718; OTTMUSP00000017719; p21ras; ras; RASH; Transforming protein p21
Gene Symbols: Hras1
Molecular weight: 21,298 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HRas

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
2 9 Y32 QNHFVDEYDPTIEDs
1 0 T35 FVDEYDPTIEDsYRK
0 10 S39‑p YDPTIEDsYRKQVVI
0 3 Y40 DPTIEDsYRKQVVID
1 5 Y64 DTAGQEEYSAMRDQY
1 0 Y96 SFEDIHQYREQIkRV
0 1 K101‑ub HQYREQIkRVKDSDD
1 0 K117 PMVLVGNKCDLAART
2 1 Y137 AQDLARSYGIPYIET
1 0 T144 YGIPYIETSAkTRQG
0 1 S145 GIPYIETSAkTRQGV
1 1 K147‑ub PYIETSAkTRQGVED
1 1 T148 YIETSAkTRQGVEDA
0 16 Y157 QGVEDAFYTLVREIR
0 1 T158 GVEDAFYTLVREIRQ
0 1 K170‑ub IRQHKLRkLNPPDEs
1 1 S177‑p kLNPPDEsGPGCMSC
1 0 S183 EsGPGCMSCKCVLS_
  human

 
Y32‑p QNHFVDEyDPtIEDs
T35‑p FVDEyDPtIEDsyRK
S39‑p yDPtIEDsyRKQVVI
Y40‑p DPtIEDsyRKQVVID
Y64‑p DTAGQEEySAMRDQY
Y96‑p SFEDIHQyREQIKRV
K101 HQyREQIKRVKDSDD
K117‑ub PMVLVGNkCDLAART
Y137‑p AQDLARSyGIPYIEt
T144‑p yGIPYIEtsAktRQG
S145‑p GIPYIEtsAktRQGV
K147‑ub PYIEtsAktRQGVED
T148‑p YIEtsAktRQGVEDA
Y157‑p QGVEDAFytLVREIR
T158‑p GVEDAFytLVREIRQ
K170 IRQHKLRKLNPPDES
S177 KLNPPDESGPGCMsC
S183‑p ESGPGCMsCKCVLS_
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.