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RYR2 ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1q43
Cellular Component: membrane; plasma membrane; protein complex; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; Z disc
Molecular Function: calcium channel activity; calcium ion binding; calcium-induced calcium release activity; calcium-release channel activity; calmodulin binding; enzyme binding; identical protein binding; protein binding; ryanodine-sensitive calcium-release channel activity
Biological Process: calcium ion transport; calcium-mediated signaling; cardiac muscle contraction; cellular calcium ion homeostasis; cytosolic calcium ion homeostasis; detection of calcium ion; positive regulation of heart rate; positive regulation of sequestering of calcium ion; regulation of heart rate; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; release of sequestered calcium ion into cytosol; response to caffeine; response to hypoxia; response to muscle activity; response to redox state
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 2; Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy
Reference #:  Q92736 (UniProtKB)
Alt. Names/Synonyms: ARVC2; ARVD2; cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Cardiac muscle-type ryanodine receptor; hRYR-2; Ryanodine receptor 2; ryanodine receptor 2 (cardiac); RYR-2; RYR2; VTSIP
Gene Symbols: RYR2
Molecular weight: 564,567 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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