ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Biological Process: calcium ion transport; calcium-mediated signaling; cardiac muscle contraction; cellular calcium ion homeostasis; cytosolic calcium ion homeostasis; detection of calcium ion; positive regulation of heart rate; positive regulation of sequestering of calcium ion; regulation of heart rate; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; release of sequestered calcium ion into cytosol; response to caffeine; response to hypoxia; response to muscle activity; response to redox state