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Protein Page:
PLA2G2F (human)

Overview
PLA2G2F PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference. Belongs to the phospholipase A2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Lipid Metabolism - arachidonic acid; Phospholipase; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; EC 3.1.1.4; Lipid Metabolism - alpha-linolenic acid; Secreted; Lipid Metabolism - ether lipid
Chromosomal Location of Human Ortholog: 1p35
Cellular Component: cytosol; extracellular region
Molecular Function: calcium ion binding; phospholipase A2 activity
Biological Process: lipid catabolic process; negative regulation of T cell proliferation; phosphatidic acid biosynthetic process
Reference #:  Q9BZM2 (UniProtKB)
Alt. Names/Synonyms: GIIF sPLA2; Group IIF secretory phospholipase A2; PA2GF; Phosphatidylcholine 2-acylhydrolase 2F; RP3-340N1.1; sPLA2-IIF
Gene Symbols: PLA2G2F
Molecular weight: 18,658 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
Select Structure to View Below

PLA2G2F

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 T6‑p __MKKFFtVAILAGs
0 1 S13‑p tVAILAGsVLstAHG
0 1 S16‑p ILAGsVLstAHGsLL
0 1 T17‑p LAGsVLstAHGsLLN
0 1 S21‑p VLstAHGsLLNLKAM
  PLA2G2F iso2  
S22‑p KVLDRCFsGWRGPRF
G26 RCFsGWRGPRFGASC
R28 FsGWRGPRFGASCPS
S35 RFGASCPSRTSRSSL
T49 LGMKKFFTVAILAGS
S56 TVAILAGSVLSTAHG
S59 ILAGSVLSTAHGSLL
T60 LAGSVLSTAHGSLLN
S64 VLSTAHGSLLNLKAM
  mouse

► Hide Isoforms
 
- gap
- gap
- gap
- gap
A6 __MKKFFAIAVLAGS
S13 AIAVLAGSVVTTAHS
T16 VLAGSVVTTAHSSLL
T17 LAGSVVTTAHSSLLN
S21 VVTTAHSSLLNLKSM
  PLA2G2F iso2  
T22 KALVKHSTGRKsPsL
S26‑p KHSTGRKsPsLRASP
S28‑p STGRKsPsLRASPsK
S34‑p PsLRASPsKTSRSSL
A48 LGMKKFFAIAVLAGS
S55 AIAVLAGSVVTTAHS
T58 VLAGSVVTTAHSSLL
T59 LAGSVVTTAHSSLLN
S63 VVTTAHSSLLNLKSM
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