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Protein Page:
FUT6 (human)

Overview
FUT6 Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates. Belongs to the glycosyltransferase 10 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.65; Transferase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: Golgi apparatus; integral to membrane
Molecular Function: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity; alpha(1,3)-fucosyltransferase activity; fucosyltransferase activity
Biological Process: L-fucose catabolic process; protein amino acid glycosylation
Disease: Fucosyltransferase 6 Deficiency
Reference #:  P51993 (UniProtKB)
Alt. Names/Synonyms: Alpha-(1,3)-fucosyltransferase; FCT3A; FLJ40754; FT1A; Fuc-TVI; Fucosyltransferase 6; fucosyltransferase 6 (alpha (1,3) fucosyltransferase); Fucosyltransferase VI; FucT-VI; FUT6
Gene Symbols: FUT6
Molecular weight: 41,860 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Select Structure to View Below

FUT6

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S123‑p PSAQLPRsPRRQGQR
0 1 Y208‑p PNSARVRyyQSLQAH
0 1 Y209‑p NSARVRyyQSLQAHL
0 1 Y221‑p AHLKVDVyGRSHKPL
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