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Protein Page:
HCN1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HCN1 Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli. Belongs to the potassium channel HCN family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5p12
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: cAMP binding; intracellular cAMP activated cation channel activity; voltage-gated potassium channel activity; voltage-gated sodium channel activity
Biological Process: regulation of membrane potential
Disease: Epileptic Encephalopathy, Early Infantile, 24
Reference #:  O60741 (UniProtKB)
Alt. Names/Synonyms: BCNG-1; BCNG1; brain cyclic nucleotide gated channel 1; Brain cyclic nucleotide-gated channel 1; HAC-2; HCN1; hyperpolarization activated cyclic nucleotide-gated potassium channel 1; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Gene Symbols: HCN1
Molecular weight: 98,796 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
Select Structure to View Below

HCN1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 7 T41 AAEKRLGTPPGGGGA
0 3 G80 GGEEPAGGFEDAEGP
0 1 K108 MLQPGVNKFSLRMFG
0 1 Y217‑p PKVIKMNyLKSWFVV
0 1 Y407‑p LDSSRRQyQEKYKQV
0 2 Y417‑p KYKQVEQyMSFHKLP
0 1 T485 NADPNFVTAMLSKLR
0 1 S489 NFVTAMLSKLRFEVF
0 1 Y513‑p GAVGKKMyFIQHGVA
0 1 K546 GEICLLTKGRRTASV
0 1 K597 RLDRIGKKNSILLQK
0 2 S599 DRIGKKNSILLQKFQ
0 1 K604 KNSILLQKFQKDLNT
0 1 K607 ILLQKFQKDLNTGVF
0 4 K623‑ub NQENEILkQIVKHDR
0 3 S846‑p VTLFRQMssGAIPPN
0 3 S847‑p TLFRQMssGAIPPNR
  mouse

 
T39‑p AADKRLGtPPGGGAA
S69‑p GGEEPAGsFEDAEGP
K97‑ub MLQPGVNkFSLRMFG
Y206 PKVIKMNYLKSWFVV
Y396 LDSSRRQYQEKYKQV
Y406‑p KYKQVEQyMSFHKLP
T474‑p NADPNFVtAMLsKLR
S478‑p NFVtAMLsKLRFEVF
Y502 GAVGKKMYFIQHGVA
K535‑ub GEICLLTkGRRTASV
K586‑ub RLDRIGKkNsILLQk
S588‑p DRIGKkNsILLQkFQ
K593‑ub kNsILLQkFQkDLNT
K596‑ub ILLQkFQkDLNTGVF
K612‑ub NQENEILkQIVKHDR
S867 VTLFRQMSSGAIPPN
S868 TLFRQMSSGAIPPNR
  rat

 
T39‑p AADKRLGtPPGGGAA
S69 GGEEPAGSFEDAEGP
K97 MLQPGVNKFSLRMFG
Y206 PKVIKMNYLKSWFVV
Y396 LDSSRRQYQEKYKQV
Y406 KYKQVEQYMSFHKLP
T474 NADPNFVTAMLSKLR
S478 NFVTAMLSKLRFEVF
Y502 GAVGKKMYFIQHGVA
K535 GEICLLTKGRRTASV
K586 RLDRIGKKNSILLQK
S588 DRIGKKNSILLQKFQ
K593 KNSILLQKFQKDLNT
K596 ILLQKFQKDLNTGVF
K612 NQENEILKQIVKHDR
S867 VTLFRQMSSGAIPPN
S868 TLFRQMSSGAIPPNR
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