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Protein Page:
CNOT6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CNOT6 Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Belongs to the CCR4/nocturin family. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; EC 3.1.13.4
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: CCR4-NOT complex; cytosol; membrane; nucleus
Molecular Function: exoribonuclease activity; metal ion binding; poly(A)-specific ribonuclease activity; protein binding; RNA binding
Biological Process: gene expression; miRNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay; poly(A) tail shortening; positive regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Reference #:  Q9ULM6 (UniProtKB)
Alt. Names/Synonyms: carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4; CCR4 carbon catabolite repression 4-like; CCR4-NOT transcription complex subunit 6; CCR4-NOT transcription complex, subunit 6; CNOT6; Cytoplasmic deadenylase; KIAA1194
Gene Symbols: CNOT6
Molecular weight: 63,307 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CNOT6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S42‑p EISGKVRsLSASLWs
0 1 S49‑p sLSASLWsLTHLtAL
0 1 T54‑p LWsLTHLtALHLSDN
0 1 T146 LYQEPDGTRRLLNYL
0 1 K162‑ub DNLSGTAkRITTEQP
0 1 S445‑p KELRYNEsLTNFSCH
  mouse

 
S42 EISGKVRSLSSSLWS
S49 SLSSSLWSLTHLTAL
T54 LWSLTHLTALHLSDN
T146‑p LCLEPDGtRRLLNYL
K162 DNLSGTAKRISTEQP
S445 KELRYNESLTNFSCN
  rat

 
S42 EISGKVRSLSSSLWS
S49 SLSSSLWSLTHLTAL
T54 LWSLTHLTALHLSDN
T146 LCLEPDGTRRLLNYL
K162 DNLSGTAKRISTEQP
S445 KELRYNESLTNFSCN
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