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Protein Page:
SLC46A1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC46A1 Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. Defects in SLC46A1 are the cause of hereditary folate malabsorption (HFM). HFM is a rare autosomal recessive disorder characterized by impaired intestinal folate absorption with folate deficiency resulting in anemia, hypoimmunoglobulinemia with recurrent infections, and recurrent or chronic diarrhea. In many patients, neurological abnormalities such as seizures or mental retardation become apparent during early childhood, attributed to impaired transport of folates into the central nervous system. When diagnosed early, the disorder can be treated by administration of folate. If untreated, it can be fatal and, if treatment is delayed, the neurological defects can become permanent. Belongs to the major facilitator superfamily. SLC46A family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, iron
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: apical plasma membrane; cell surface; cytoplasm; plasma membrane
Molecular Function: folic acid transporter activity; heme transporter activity; hydrogen ion transmembrane transporter activity; methotrexate transporter activity
Biological Process: cellular iron ion homeostasis; folic acid metabolic process; folic acid transport; methotrexate transport
Disease: Folate Malabsorption, Hereditary
Reference #:  Q96NT5 (UniProtKB)
Alt. Names/Synonyms: FLJ39875; G21; HCP1; Heme carrier protein 1; MGC9564; PCFT; PCFT/HCP1; Proton-coupled folate transporter; SLC46A1; solute carrier family 46 (folate transporter), member 1; Solute carrier family 46 member 1
Gene Symbols: SLC46A1
Molecular weight: 49,771 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Select Structure to View Below

SLC46A1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 7 S6‑p __MEGSAsPPEkPRA
0 1 K10‑ub GSAsPPEkPRARPAA
0 1 Y255 HRSIVQLYVAPAPEk
0 3 K262‑ub YVAPAPEkSRKHLAL
0 1 S263 VAPAPEkSRKHLALY
0 22 S458‑p EFQQFPQsP______
  mouse

 
S6 __MEGRVSSVGSPHS
S10 GRVSSVGSPHSFLNA
Y255‑p HRSIARLyVVPAPEK
K262 yVVPAPEKsRMHLAL
S263‑p VVPAPEKsRMHLALY
S458‑p EFQQFPQsP______
  rat

 
S6‑p __MEGRVsPVGSSHR
S10 GRVsPVGSSHRLLTA
Y255 HRSIVQLYVVPAPEK
K262 YVVPAPEKSRMHLAL
S263 VVPAPEKSRMHLALY
N458 EFQQFPQNS______
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