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Protein Page:
MGLL (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MGLL Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family. Note: This description may include information from UniProtKB.
Protein type: Phospholipase; Lipid Metabolism - glycerolipid; EC 3.1.1.23
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component: cytosol; endoplasmic reticulum membrane; extrinsic to membrane; membrane; nucleoplasm; plasma membrane
Molecular Function: acylglycerol lipase activity; lysophospholipase activity; protein homodimerization activity
Biological Process: acylglycerol catabolic process; arachidonic acid metabolic process; inflammatory response; lipid metabolic process; regulation of inflammatory response; regulation of sensory perception of pain; regulation of signal transduction
Reference #:  Q99685 (UniProtKB)
Alt. Names/Synonyms: HU-K5; HUK5; Lysophospholipase homolog; Lysophospholipase-like; MAGL; MGL; MGLL; monoacylglycerol lipase; Monoglyceride lipase
Gene Symbols: MGLL
Molecular weight: 33,261 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
Select Structure to View Below

MGLL

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T10 EESSPRRTPQSIPYQ
0 1 Y16 RTPQSIPYQDLPHLV
0 1 Y29 LVNADGQYLFCRYWK
0 1 K36 YLFCRYWKPTGTPKA
0 1 T38 FCRYWKPTGTPKALI
0 1 T40 RYWKPTGTPKALIFV
0 1 S48 PKALIFVSHGAGEHS
0 1 S182 SLGPIDSSVLSRNKT
0 1 K188 SSVLSRNKTEVDIYN
0 11 T189 SVLSRNKTEVDIYNS
0 1 S196 TEVDIYNSDPLICRA
0 1 S237 PFLLLQGSADRLCDS
0 1 K245 ADRLCDSKGAyLLME
0 1 Y248‑p LCDSKGAyLLMELAK
0 1 S301‑p TATAGTAsPP_____
  mouse

► Hide Isoforms
 
T10‑p EASSPRRtPQNVPYQ
Y16 RtPQNVPYQDLPHLV
Y29 LVNADGQYLFCRYWk
K36‑ub YLFCRYWkPsGtPKA
S38‑p FCRYWkPsGtPKALI
T40‑p RYWkPsGtPKALIFV
S48‑p PKALIFVsHGAGEHC
S182 TLGRIDSSVLSRNks
K188‑ub SSVLSRNksEVDLYN
S189‑p SVLSRNksEVDLYNs
S196‑p sEVDLYNsDPLVCRA
S237 PFLLLQGSADRLCDS
K245‑ub ADRLCDSkGAYLLME
Y248 LCDSkGAYLLMESSR
C301 IAAAGAGCPP_____
  MGLL iso2  
T10 EASSPRRTPQNVPYQ
Y16 RTPQNVPYQDLPHLV
Y29 LVNADGQYLFCRYWK
K36 YLFCRYWKPSGTPKA
S38 FCRYWKPSGTPKALI
T40 RYWKPSGTPKALIFV
S48 PKALIFVSHGAGEHC
S182‑p TLGRIDSsVLSRNKS
K188 SsVLSRNKSEGsADR
S189 sVLSRNKSEGsADRL
- gap
S192‑p SRNKSEGsADRLCDS
K200 ADRLCDSKGAYLLME
Y203 LCDSKGAYLLMESSR
C256 IAAAGAGCPP_____
  rat

 
T10 EASSPRRTPQNVPyQ
Y16‑p RTPQNVPyQDLPHLV
Y29‑p LVNADGQyLFCRYWK
K36 yLFCRYWKPSGTPKA
S38 FCRYWKPSGTPKALI
T40 RYWKPSGTPKALIFV
S48 PKALIFVSHGAGEHC
S182 SLGRIDSSVLSRNKs
K188 SSVLSRNKsEVDLYN
S189‑p SVLSRNKsEVDLYNS
S196 sEVDLYNSDPLICHA
S237 PFLLLQGSADRLCDS
K245 ADRLCDSKGAYLLME
Y248 LCDSKGAYLLMESSP
C301 IAVAGARCLP_____
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