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Protein Page:
CATSPER3 (human)

Overview
CATSPER3 Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: plasma membrane
Molecular Function: cation channel activity
Biological Process: calcium ion transport; response to progesterone stimulus; sperm-egg recognition
Reference #:  Q86XQ3 (UniProtKB)
Alt. Names/Synonyms: Ca(v)-like protein; CACRC; calcium channel repeat containing 1; Cation channel sperm-associated protein 3; cation channel, sperm associated 3; CATSPER3; CTSR3; MGC126741; One-repeat calcium channel-like protein; putative ion channel CatSper3
Gene Symbols: CATSPER3
Molecular weight: 46,422 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Select Structure to View Below

CATSPER3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T140‑p QLMGKQFtYLYIADG
0 1 S150‑p YIADGMQsLRILKLI
0 1 T334 FKKTLSHTDPMVLDD
0 1 T344 MVLDDFGTSLPFIDI
0 1 S345 VLDDFGTSLPFIDIY
  mouse

 
A140 KIKGNHSAYLHFADG
S150 HFADGIQSLRILKLI
T333 FKKTLRHTDPMVLDD
T343 MVLDDFSTSLSFIDI
S344 VLDDFSTSLSFIDIY
  rat

 
E117 KIKGNHFEYLHFADG
S127 HFADGIQSLRVLKLI
T310‑p FKRTLRHtDPMVLDE
T320‑p MVLDEFCtsLSFIDI
S321‑p VLDEFCtsLSFIDIY
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