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Protein Page:
CANT1 (human)

Overview
CANT1 Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis. Defects in CANT1 are the cause of Desbuquois dysplasia (DBQD). A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of Desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations. Belongs to the apyrase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleotide Metabolism - pyrimidine; EC 3.6.1.6; Membrane protein, integral; Hydrolase; Endoplasmic reticulum; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 17q25.3
Molecular Function: guanosine-diphosphatase activity; signal transducer activity; uridine-diphosphatase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; proteoglycan biosynthetic process
Disease: Desbuquois Dysplasia 1
Reference #:  Q8WVQ1 (UniProtKB)
Alt. Names/Synonyms: Apyrase homolog; Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase; calcium activated nucleotidase 1; CANT1; DBQD; Putative MAPK-activating protein PM09; Putative NF-kappa-B-activating protein 107; SCAN-1; SCAN1; SHAPY; soluble Ca-activated nucleotidase, isozyme 1; Soluble calcium-activated nucleotidase 1; soluble calcium-activated nucleotidase SCAN-1
Gene Symbols: CANT1
Molecular weight: 44,840 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Select Structure to View Below

CANT1

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S17‑p EWNESMHsLRIsVGG
0 2 S21‑p SMHsLRIsVGGLPVL
0 1 Y133‑p FSYLKKGyLTLsDsG
0 1 S137‑p KKGyLTLsDsGDKVA
0 1 S139‑p GyLTLsDsGDKVAVE
0 1 S156‑p KDHGVLEsHLAEKGR
0 1 S202‑p AVPWVILsDGDGTVE
0 1 S303‑p FFLPRRAsQERYSEK
  mouse

 
S17 EWNEPMHSLRIsVGG
S21‑p PMHSLRIsVGGLPVL
Y135 FSYLKKGYLTLSDSG
S139 KKGYLTLSDSGDRVS
S141 GYLTLSDSGDRVSVE
S158 KDHGVLESHLAEKGR
S204 AVPWVILSDGDGTVE
S305 FFLPRRASHERYSEK
  rat

 
S17 EWNEPMHSLRISVGG
S21 PMHSLRISVGGLPVL
Y135 FSYLKKGYLTLSDSG
S139 KKGYLTLSDSGDRVS
S141 GYLTLSDSGDRVSVE
S158 KDRGVLESHLAEKGR
S204 AVPWVILSDGDGAVE
S305 FFLPRRASHERYSER
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