Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
IFNB1 (human)

Overview
IFNB1 Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 9p21
Cellular Component: extracellular region; extracellular space
Molecular Function: chloramphenicol O-acetyltransferase activity; cytokine activity; interferon-alpha/beta receptor binding
Biological Process: B cell activation during immune response; B cell differentiation; B cell proliferation; blood coagulation; cell surface receptor linked signal transduction; defense response to virus; humoral immune response; natural killer cell activation during immune response; negative regulation of T cell differentiation; negative regulation of viral genome replication; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of transcription from RNA polymerase II promoter; response to exogenous dsRNA; T cell activation during immune response
Reference #:  P01574 (UniProtKB)
Alt. Names/Synonyms: Fibroblast interferon; IFB; IFF; IFN-beta; IFNB; IFNB1; Interferon beta; interferon, beta 1, fibroblast; MGC96956
Gene Symbols: IFNB1
Molecular weight: 22,294 Da
Basal Isoelectric point: 8.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IFNB1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 - gap
0 1 T18 LLLCFSTTALSMSYN
0 1 Y24 TTALSMSYNLLGFLQ
0 1 S140‑p TRGKLMSsLHLKRYY
  mouse

 
- gap
T18 FLLCFSTTALSINYK
Y24 TTALSINYKQLQLQE
A135 TWEMSSTALHLKSYY
  rat

 
T6‑p __MANRWtLHIAFLL
T18‑p FLLCFSTtALSIDyK
Y24‑p TtALSIDyKQLQFRQ
T137 TWVTSTTTLGLKSYY
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.