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Protein Page:
C1QB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
C1QB C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QB are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component: complement component C1 complex; extracellular region
Molecular Function: protein binding; serine-type endopeptidase activity
Biological Process: complement activation; complement activation, classical pathway
Disease: C1q Deficiency
Reference #:  P02746 (UniProtKB)
Alt. Names/Synonyms: C1QB; Complement C1q subcomponent subunit B; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide; complement component C1q, B chain; complement subcomponent C1q chain B
Gene Symbols: C1QB
Molecular weight: 26,722 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
Select Structure to View Below

C1QB

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K77‑m3 DHGEFGEkGDPGIPG
0 1 K88‑m3 GIPGNPGkVGPkGPM
0 1 K92‑m3 NPGkVGPkGPMGPKG
0 1 S125‑p ATQKIAFsAtRtINV
0 1 T127‑p QKIAFsAtRtINVPL
0 1 T129‑p IAFsAtRtINVPLRR
0 1 H144 DQTIRFDHVITNMNN
0 1 Y168‑p TCKVPGLyYFTYHAS
  mouse

 
K75 DLGEFGEKGDPGIPG
K86 GIPGTPGKVGPKGPV
K90 TPGKVGPKGPVGPKG
S123 ATQKVAFSALRTINS
L125 QKVAFSALRTINSPL
T127 VAFSALRTINSPLRP
K142 NQVIRFEKVITNANE
Y166 TCKVPGLYYFTYHAS
  rat

 
K75 DHGELGEKGDAGIPG
K86 GIPGIPGKVGPKGPV
K90 IPGKVGPKGPVGPKG
S123 ATQKVAFSALRTVNS
L125 QKVAFSALRTVNSAL
T127 VAFSALRTVNSALRP
K142‑ac NQAIRFEkVITNVND
Y166 TCKVPGLYYFTYHAS
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