Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
Oct7 (human)

Overview
Oct7 Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters. Interacts with PQBP1. Expressed specifically in the neuroectodermal cell lineage. Belongs to the POU transcription factor family. Class- 3 subfamily. 3 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q16
Cellular Component: nucleus; transcription factor complex
Molecular Function: identical protein binding; protein binding; transcription factor activity
Biological Process: astrocyte development; cerebral cortex radially oriented cell migration; epidermis development; forebrain ventricular zone progenitor cell division; hypothalamus cell differentiation; myelination in the peripheral nervous system; neurohypophysis development; neuron differentiation; positive regulation of cell proliferation; positive regulation of multicellular organism growth; positive regulation of transcription from RNA polymerase II promoter; regulation of axonogenesis; transcription from RNA polymerase II promoter
Reference #:  P20265 (UniProtKB)
Alt. Names/Synonyms: Brain-2; Brain-specific homeobox/POU domain protein 2; Brn-2; BRN2; Nervous system-specific octamer-binding transcription factor N-Oct-3; Oct-7; OCT7; Octamer-binding protein 7; Octamer-binding transcription factor 7; OTF-7; OTF7; PO3F2; POU class 3 homeobox 2; POU domain, class 3, transcription factor 2; POU3F2; POUF3
Gene Symbols: POU3F2
Molecular weight: 46,893 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Oct7

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
transcription, altered: S360‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S339‑p LEEADSSsGsPTSID
0 6 S341‑p EADSSsGsPTSIDKI
1 0 T359 GRKRKKRTsIEVSVK
2 1 S360‑p RKRKKRTsIEVSVKG
0 1 S429‑p AEDVYGGsRDtPPHH
0 6 T432‑p VYGGsRDtPPHHGVQ
0 4 T440‑p PPHHGVQtPVQ____
  mouse

 
S341 LEEADSSSGSPTSID
S343 EADSSSGSPTSIDKI
T361‑p GRKRKKRtsIEVSVK
S362‑p RKRKKRtsIEVSVKG
S431 AEDVYGGSRDtPPHH
T434‑p VYGGSRDtPPHHGVQ
T442‑p PPHHGVQtPVQ____
  rat

 
S341 LEEADSSSGSPTSID
S343 EADSSSGSPTSIDKI
T361 GRKRKKRTSIEVSVK
S362 RKRKKRTSIEVSVKG
S431 AEDVYGGSRDTPPHH
T434 VYGGSRDTPPHHGVQ
T442 PPHHGVQTPVQ____
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.