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Protein Page:
ADAMTS10 (human)

ADAMTS10 Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. Defects in ADAMTS10 are the cause of Weill-Marchesani syndrome 1 (WMS1). WMS1 is a rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: extracellular matrix; microfibril
Molecular Function: protein binding
Disease: Weill-marchesani Syndrome 1
Reference #:  Q9H324 (UniProtKB)
Alt. Names/Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 10; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10; ADAM metallopeptidase with thrombospondin type 1 motif, 10; ADAM-TS 10; ADAM-TS10; ADAMTS-10; ADAMTS10; ATS10; WMS; zinc metalloendopeptidase
Gene Symbols: ADAMTS10
Molecular weight: 120,874 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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