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Protein Page:
A6r (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
A6r Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component: filopodium; growth cone; lamellipodium; myofibril; perinuclear region of cytoplasm; stereocilium
Molecular Function: actin monomer binding; ATP binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein kinase C binding
Biological Process: barbed-end actin filament capping; negative regulation of actin filament polymerization; positive regulation of axon extension; regulation of actin cytoskeleton organization and biogenesis; regulation of microvillus length; sequestering of actin monomers
Reference #:  Q6IBS0 (UniProtKB)
Alt. Names/Synonyms: A6-related protein; A6r; A6RP; hA6RP; MSTP011; Protein tyrosine kinase 9-like; protein tyrosine kinase 9-like (A6-related protein); PTK9L; PTK9L protein tyrosine kinase 9-like (A6-related protein); TWF2; twinfilin, actin-binding protein, homolog 2 (Drosophila); Twinfilin-1-like protein; Twinfilin-2
Gene Symbols: TWF2
Molecular weight: 39,548 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
Select Structure to View Below

A6r

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K14‑ac IHATEELkEFFAkAR
0 1 K19‑ac ELkEFFAkARAGSVR
0 1 S24 FAkARAGSVRLIKVV
0 1 K109‑ac AATRATVkkEFGGGH
0 1 K110‑ac ATRATVkkEFGGGHI
0 1 T148‑p CAAPAPLtSAERELQ
0 1 K163‑sm QIRINEVkTEIsVES
0 2 S167‑p NEVkTEIsVESKHQT
0 516 Y309‑p ELTAEFLyDEVHPKQ
0 26 S349‑p PGENGDDs_______
  mouse

 
K14 IHATEELKEFFAKAR
K19 ELKEFFAKARAGsIR
S24‑p FAKARAGsIRLIKVI
K109 AATRATVKKEFGGGH
K110 ATRATVKKEFGGGHI
T148 CAAPAPLTSAERELQ
K163 QIRINEVKTEIsVES
S167‑p NEVKTEIsVESKHQT
Y309‑p ELTAEFLyDEVHPKQ
S349‑p PGENGEDs_______
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