Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
COX-2 (human)

COX-2 Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - arachidonic acid; Oxidoreductase
Chromosomal Location of Human Ortholog: 1q25.2-q25.3
Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; neuron projection; nucleus
Molecular Function: arachidonate 15-lipoxygenase activity; enzyme binding; heme binding; peroxidase activity; prostaglandin-endoperoxide synthase activity; protein binding
Biological Process: cell motility; cyclooxygenase pathway; lipoxygenase pathway; nicotinamide metabolic process; positive regulation of fever; positive regulation of nitric oxide biosynthetic process; prostaglandin biosynthetic process; prostaglandin metabolic process; regulation of blood pressure
Reference #:  P35354 (UniProtKB)
Alt. Names/Synonyms: COX-2; COX2; cyclooxygenase 2b; Cyclooxygenase-2; GRIPGHS; hCox-2; PGG/HS; PGH synthase 2; PGH2; PGHS-2; PHS II; PHS-2; Prostaglandin G/H synthase 2; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); PTGS2
Gene Symbols: PTGS2
Molecular weight: 68,996 Da
Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene