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Protein Page:
COX-2 (human)

Overview
COX-2 Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.14.99.1
Chromosomal Location of Human Ortholog: 1q25.2-q25.3
Cellular Component: caveola; cytoplasm; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; neuron projection; nucleus; protein complex
Molecular Function: arachidonate 15-lipoxygenase activity; enzyme binding; heme binding; lipid binding; metal ion binding; peroxidase activity; prostaglandin-endoperoxide synthase activity; protein binding; protein homodimerization activity
Biological Process: angiogenesis; arachidonic acid metabolic process; bone mineralization; brown fat cell differentiation; cell motility; cyclooxygenase pathway; decidualization; embryo implantation; hair cycle; inflammatory response; learning; lipoxygenase pathway; memory; NAD metabolic process; negative regulation of calcium ion transport; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of smooth muscle contraction; negative regulation of synaptic transmission, dopaminergic; nicotinamide metabolic process; ovulation; positive regulation of apoptosis; positive regulation of fever; positive regulation of NF-kappaB import into nucleus; positive regulation of nitric oxide biosynthetic process; positive regulation of prostaglandin biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of synaptic plasticity; positive regulation of synaptic transmission, glutamatergic; positive regulation of vasoconstriction; prostaglandin biosynthetic process; prostaglandin metabolic process; regulation of blood pressure; regulation of inflammatory response; response to drug; response to estradiol stimulus; response to fructose stimulus; response to glucocorticoid stimulus; response to lipopolysaccharide; response to lithium ion; response to manganese ion; response to oxidative stress; response to vitamin D; sensory perception of pain; vitamin metabolic process; water-soluble vitamin metabolic process
Reference #:  P35354 (UniProtKB)
Alt. Names/Synonyms: COX-2; COX2; cyclooxygenase 2b; Cyclooxygenase-2; GRIPGHS; hCox-2; PGG/HS; PGH synthase 2; PGH2; PGHS-2; PHS II; PHS-2; Prostaglandin G/H synthase 2; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); PTGS2
Gene Symbols: PTGS2
Molecular weight: 68,996 Da
Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

COX-2

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: Y446‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y120‑p PPTYNADyGYKSWEA
0 1 Y248 QIIDGEMYPPTVKDT
0 1 S437 VQKVSQASIDQSRQM
1 1 Y446‑p DQSRQMKyQSFNEYR
0 1 M457 NEYRKRFMLKPYESF
  mouse

 
Y120 PPTYNVHYGYKSWEA
Y248 QVIGGEVYPPTVKDT
S437‑p VQAVAKAsIDQSREM
Y446‑p DQSREMKyQSLNEYR
S457‑p NEYRKRFsLKPYTSF
  rat

 
Y120 PPTYNVHYGYKSWEA
Y248‑p QVIGGEVyPPTVKDT
S437 VQAVAKASIDQSREM
Y446 DQSREMKYQSLNEYR
S457 NEYRKRFSLKPYTSF
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