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Protein Page:
COX-2 (mouse)

Overview
COX-2 Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.99.1; Oxidoreductase; Lipid Metabolism - arachidonic acid
Cellular Component: caveola; cytoplasm; endoplasmic reticulum; intracellular membrane-bound organelle; membrane; neuron projection; nucleus; protein complex
Molecular Function: dioxygenase activity; enzyme binding; heme binding; lipid binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; peroxidase activity; prostaglandin-endoperoxide synthase activity; protein homodimerization activity
Biological Process: anagen; angiogenesis; bone mineralization; brown fat cell differentiation; cyclooxygenase pathway; decidualization; embryo implantation; fatty acid biosynthetic process; fatty acid metabolic process; inflammatory response; keratinocyte differentiation; learning; lipid metabolic process; memory; negative regulation of calcium ion transport; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of smooth muscle contraction; negative regulation of synaptic transmission, dopaminergic; ovulation; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of fever; positive regulation of NF-kappaB import into nucleus; positive regulation of nitric oxide biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of synaptic plasticity; positive regulation of synaptic transmission, glutamatergic; positive regulation of vasoconstriction; prostaglandin biosynthetic process; prostaglandin metabolic process; regulation of blood pressure; regulation of cell proliferation; response to cytokine stimulus; response to lipopolysaccharide; response to oxidative stress; sensory perception of pain
Reference #:  Q05769 (UniProtKB)
Alt. Names/Synonyms: COX-2; Cox2; cyclooxygenase 2; Cyclooxygenase-2; Glucocorticoid-regulated inflammatory cyclooxygenase; Gripghs; Macrophage activation-associated marker protein P71/73; PES-2; PGH synthase 2; PGH2; PGHS-2; Pghs-b; Pghs2; PHS II; PHS-2; Prostaglandin G/H synthase 2; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; Ptgs2; Tis10; TIS10 protein
Gene Symbols: Ptgs2
Molecular weight: 69,013 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

COX-2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 0 Y120 PPTYNVHYGYKSWEA
0 1 Y248 QVIGGEVYPPTVKDT
0 1 S437‑p VQAVAKAsIDQSREM
1 1 Y446‑p DQSREMKyQSLNEYR
0 1 S457‑p NEYRKRFsLKPYTSF
  human

 
Y120‑p PPTYNADyGYKSWEA
Y248 QIIDGEMYPPTVKDT
S437 VQKVSQASIDQSRQM
Y446‑p DQSRQMKyQSFNEYR
M457 NEYRKRFMLKPYESF
  rat

 
Y120 PPTYNVHYGYKSWEA
Y248‑p QVIGGEVyPPTVKDT
S437 VQAVAKASIDQSREM
Y446 DQSREMKYQSLNEYR
S457 NEYRKRFSLKPYTSF
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