Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
COX-2 (mouse)

COX-2 Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - arachidonic acid; Oxidoreductase
Cellular Component: caveola; cytoplasm; endoplasmic reticulum; neuron projection; nucleus; protein complex
Molecular Function: enzyme binding; heme binding; lipid binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; prostaglandin-endoperoxide synthase activity; protein homodimerization activity
Biological Process: anagen; angiogenesis; bone mineralization; brown fat cell differentiation; cyclooxygenase pathway; decidualization; embryo implantation; inflammatory response; learning; memory; negative regulation of calcium ion transport; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of smooth muscle contraction; negative regulation of synaptic transmission, dopaminergic; ovulation; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of fever; positive regulation of NF-kappaB import into nucleus; positive regulation of nitric oxide biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of synaptic plasticity; positive regulation of synaptic transmission, glutamatergic; positive regulation of vasoconstriction; prostaglandin biosynthetic process; regulation of blood pressure; regulation of cell proliferation; response to cytokine stimulus; response to lipopolysaccharide; sensory perception of pain
Reference #:  Q05769 (UniProtKB)
Alt. Names/Synonyms: COX-2; Cox2; cyclooxygenase 2; Cyclooxygenase-2; Glucocorticoid-regulated inflammatory cyclooxygenase; Gripghs; Macrophage activation-associated marker protein P71/73; PES-2; PGH synthase 2; PGH2; PGHS-2; Pghs-b; Pghs2; PHS II; PHS-2; Prostaglandin G/H synthase 2; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; Ptgs2; Tis10; TIS10 protein
Gene Symbols: Ptgs2
Molecular weight: 69,013 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene