Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 188.8.131.52
Molecular Function: enzyme binding; heme binding; lipid binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; prostaglandin-endoperoxide synthase activity; protein homodimerization activity
Biological Process: anagen; angiogenesis; bone mineralization; brown fat cell differentiation; cyclooxygenase pathway; decidualization; embryo implantation; inflammatory response; learning; memory; negative regulation of calcium ion transport; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of smooth muscle contraction; negative regulation of synaptic transmission, dopaminergic; ovulation; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of fever; positive regulation of NF-kappaB import into nucleus; positive regulation of nitric oxide biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of synaptic plasticity; positive regulation of synaptic transmission, glutamatergic; positive regulation of vasoconstriction; prostaglandin biosynthetic process; regulation of blood pressure; regulation of cell proliferation; response to cytokine stimulus; response to lipopolysaccharide; sensory perception of pain
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.